Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Incarnate Word | 41 | Youngstown State | 44 | Final(OT) | W | 3 |
| 2 | 2021-09-11 | Youngstown State | 14 | Michigan State | 42 | Final | L | -28 |
| 3 | 2021-09-25 | Western Illinois | 38 | Youngstown State | 35 | Final | L | -3 |
| 4 | 2021-10-02 | Youngstown State | 7 | Northern Iowa | 34 | Final | L | -27 |
| 5 | 2021-10-09 | Missouri State | 33 | Youngstown State | 41 | Final | W | 8 |
| 6 | 2021-10-23 | Youngstown State | 17 | Indiana State | 28 | Final | L | -11 |
| 7 | 2021-10-30 | South Dakota State | 47 | Youngstown State | 16 | Final | L | -31 |
| 8 | 2021-11-06 | Youngstown State | 21 | North Dakota | 24 | Final | L | -3 |
| 9 | 2021-11-13 | North Dakota State | 49 | Youngstown State | 17 | Final | L | -32 |
| 10 | 2021-11-20 | Youngstown State | 35 | Southern Illinois | 18 | Final | W | 17 |