Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Western Illinois | 21 | Ball State | 31 | Final | L | -10 |
| 2 | 2021-09-11 | Western Illinois | 7 | Montana | 42 | Final | L | -35 |
| 3 | 2021-09-18 | Eastern Washington | 62 | Western Illinois | 56 | Final | L | -6 |
| 4 | 2021-09-25 | Western Illinois | 38 | Youngstown State | 35 | Final | W | 3 |
| 5 | 2021-10-02 | Southern Illinois | 31 | Western Illinois | 30 | Final(OT) | L | -1 |
| 6 | 2021-10-09 | Western Illinois | 27 | Indiana State | 37 | Final | L | -10 |
| 7 | 2021-10-16 | South Dakota State | 41 | Western Illinois | 17 | Final | L | -24 |
| 8 | 2021-10-23 | Western Illinois | 10 | North Dakota | 34 | Final | L | -24 |
| 9 | 2021-10-30 | Illinois State | 31 | Western Illinois | 38 | Final | W | 7 |
| 10 | 2021-11-06 | South Dakota | 42 | Western Illinois | 21 | Final | L | -21 |
| 11 | 2021-11-20 | Western Illinois | 3 | Northern Iowa | 41 | Final | L | -38 |