Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Northern Illinois | 22 | Georgia Tech | 21 | Final | L | -1 |
| 2 | 2021-09-11 | Kennesaw State | 17 | Georgia Tech | 45 | Final | W | 28 |
| 3 | 2021-09-18 | Georgia Tech | 8 | Clemson | 14 | Final | L | -6 |
| 4 | 2021-09-25 | North Carolina | 22 | Georgia Tech | 45 | Final | W | 23 |
| 5 | 2021-10-02 | Pittsburgh | 52 | Georgia Tech | 21 | Final | L | -31 |
| 6 | 2021-10-09 | Georgia Tech | 31 | Duke | 27 | Final | W | 4 |
| 7 | 2021-10-23 | Georgia Tech | 40 | Virginia | 48 | Final | L | -8 |
| 8 | 2021-10-30 | Virginia Tech | 26 | Georgia Tech | 17 | Final | L | -9 |
| 9 | 2021-11-06 | Georgia Tech | 30 | Miami | 33 | Final | L | -3 |
| 10 | 2021-11-13 | Boston College | 41 | Georgia Tech | 30 | Final | L | -11 |
| 11 | 2021-11-20 | Georgia Tech | 0 | Notre Dame | 55 | Final | L | -55 |
| 12 | 2021-11-27 | Georgia (1) | 45 | Georgia Tech (98) | 0 | Final | L | -45 |