Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Tulane | 35 | Oklahoma | 40 | Final | L | -5 |
| 2 | 2021-09-11 | Morgan State | 20 | Tulane | 69 | Final | W | 49 |
| 3 | 2021-09-18 | Tulane | 21 | Ole Miss | 61 | Final | L | -40 |
| 4 | 2021-09-25 | UAB | 28 | Tulane | 21 | Final | L | -7 |
| 5 | 2021-10-02 | Tulane | 29 | East Carolina | 52 | Final | L | -23 |
| 6 | 2021-10-07 | Houston | 40 | Tulane | 22 | Final | L | -18 |
| 7 | 2021-10-21 | Tulane | 26 | SMU | 55 | Final | L | -29 |
| 8 | 2021-10-30 | Cincinnati | 31 | Tulane | 12 | Final | L | -19 |
| 9 | 2021-11-06 | Tulane | 10 | Central Florida | 14 | Final | L | -4 |
| 10 | 2021-11-13 | Tulsa | 20 | Tulane | 13 | Final(OT) | L | -7 |
| 11 | 2021-11-19 | South Florida | 0 | Tulane | 0 | Cancelled | - | - |
| 12 | 2021-11-20 | South Florida | 14 | Tulane | 45 | Final | W | 31 |
| 13 | 2021-11-27 | Tulane (119) | 28 | Memphis (84) | 33 | Final | L | -5 |