Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-01 | Mars Hill | 7 | Samford | 77 | Final | W | 70 |
| 2 | 2016-09-10 | Samford | 35 | Central Arkansas | 29 | Final | W | 6 |
| 3 | 2016-09-24 | Samford | 21 | Chattanooga | 41 | Final | L | -20 |
| 4 | 2016-10-01 | Wofford | 26 | Samford | 28 | Final | W | 2 |
| 5 | 2016-10-08 | Samford | 38 | Furman | 21 | Final | W | 17 |
| 6 | 2016-10-15 | Virginia Military | 21 | Samford | 55 | Final | W | 34 |
| 7 | 2016-10-22 | Western Carolina | 17 | Samford | 30 | Final | W | 13 |
| 8 | 2016-10-29 | Samford | 41 | Mississippi State | 56 | Final | L | -15 |
| 9 | 2016-11-05 | Samford (131) | 34 | The Citadel (108) | 37 | Final/OT | L | -3 |
| 10 | 2016-11-12 | Mercer (170) | 19 | Samford (133) | 24 | Final | W | 5 |
| 11 | 2016-11-19 | Samford | 14 | East Tennessee State | 15 | Final | L | -1 |
| 12 | 2016-11-26 | Samford | 24 | Youngstown State | 38 | Final | L | -14 |