Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Tarleton State | 3 | McNeese State | 33 | Final | W | 30 |
| 2 | 2016-09-10 | McNeese State | 22 | Louisiana | 30 | Final | L | -8 |
| 3 | 2016-09-17 | Stephen F. Austin | 31 | McNeese State | 28 | Final | L | -3 |
| 4 | 2016-09-24 | McNeese State | 42 | Incarnate Word | 35 | Final | W | 7 |
| 5 | 2016-10-01 | Nicholls State | 13 | McNeese State | 38 | Final | W | 25 |
| 6 | 2016-10-08 | McNeese State | 24 | Southeastern Louisiana | 31 | Final | L | -7 |
| 7 | 2016-10-15 | Central Arkansas | 35 | McNeese State | 0 | Final | L | -35 |
| 8 | 2016-10-22 | McNeese State | 48 | Northwestern State | 27 | Final | W | 21 |
| 9 | 2016-10-29 | Abilene Christian | 14 | McNeese State | 33 | Final | W | 19 |
| 10 | 2016-11-05 | McNeese State | 43 | Sam Houston State | 56 | Final | L | -13 |
| 11 | 2016-11-19 | Lamar | 10 | McNeese State | 41 | Final | W | 31 |