Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Southern | 21 | Louisiana-Monroe | 38 | Final | L | -17 |
| 2 | 2016-09-10 | Southern | 21 | Tulane | 66 | Final | L | -45 |
| 3 | 2016-09-17 | Alabama State | 6 | Southern | 64 | Final | W | 58 |
| 4 | 2016-09-24 | Southern | 59 | Alabama A&M | 31 | Final | W | 28 |
| 5 | 2016-10-15 | Southern | 28 | Jackson State | 24 | Final | W | 4 |
| 6 | 2016-10-22 | Arkansas-Pine Bluff | 17 | Southern | 49 | Final | W | 32 |
| 7 | 2016-10-29 | Southern (157) | 41 | Alcorn State (202) | 33 | Final | W | 8 |
| 8 | 2016-11-05 | Texas Southern (228) | 10 | Southern (156) | 26 | Final | W | 16 |
| 9 | 2016-11-12 | Southern | 44 | Prairie View A&M | 34 | Final | W | 10 |
| 10 | 2016-11-19 | Mississippi Valley State | 0 | Southern | 55 | Final | W | 55 |
| 11 | 2016-11-26 | Grambling | 52 | Southern | 30 | Final | L | -22 |