Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-02 | Sacred Heart (192) | 0 | Lafayette (235) | 6 | Final | W | 6 |
| 2 | 2022-09-03 | Sacred Heart (192) | 0 | Lafayette (235) | 6 | Final | W | 6 |
| 3 | 2022-09-10 | Lafayette (235) | 14 | Temple (143) | 30 | Final | L | -16 |
| 4 | 2022-09-17 | William & Mary (96) | 34 | Lafayette (173) | 7 | Final | L | -27 |
| 5 | 2022-09-24 | Lafayette (182) | 0 | Penn (150) | 12 | Final | L | -12 |
| 6 | 2022-10-01 | Lafayette (178) | 24 | Bucknell (250) | 14 | Final | W | 10 |
| 7 | 2022-10-08 | Princeton (134) | 23 | Lafayette (183) | 2 | Final | L | -21 |
| 8 | 2022-10-22 | Holy Cross (79) | 24 | Lafayette (179) | 21 | Final | L | -3 |
| 9 | 2022-10-29 | Georgetown (234) | 30 | Lafayette (200) | 20 | Final | L | -10 |
| 10 | 2022-11-05 | Lafayette (194) | 21 | Colgate (205) | 16 | Final | W | 5 |
| 11 | 2022-11-12 | Lafayette (198) | 10 | Fordham (143) | 45 | Final | L | -35 |
| 12 | 2022-11-19 | Lehigh (234) | 11 | Lafayette (197) | 14 | Final | W | 3 |