Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-17 | Yale (202) | 14 | Holy Cross (107) | 38 | Final | L | -24 |
| 2 | 2022-09-24 | Yale (169) | 38 | Cornell (192) | 14 | Final | W | 24 |
| 3 | 2022-10-01 | Howard (235) | 26 | Yale (161) | 34 | Final | W | 8 |
| 4 | 2022-10-08 | Dartmouth (213) | 21 | Yale (159) | 24 | Final | W | 3 |
| 5 | 2022-10-15 | Bucknell (255) | 9 | Yale (160) | 27 | Final | W | 18 |
| 6 | 2022-10-22 | Yale (159) | 13 | Penn (127) | 20 | Final | L | -7 |
| 7 | 2022-10-28 | Yale (160) | 41 | Columbia (203) | 16 | Final | W | 25 |
| 8 | 2022-11-05 | Brown (204) | 17 | Yale (151) | 69 | Final | W | 52 |
| 9 | 2022-11-12 | Princeton (137) | 20 | Yale (141) | 24 | Final | W | 4 |
| 10 | 2022-11-19 | Yale (134) | 19 | Harvard (171) | 14 | Final | W | 5 |