Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Cincinnati (5) | 24 | Arkansas (20) | 31 | Final | L | -7 |
| 2 | 2022-09-10 | Kennesaw State (122) | 10 | Cincinnati (5) | 63 | Final | W | 53 |
| 3 | 2022-09-17 | Cincinnati (52) | 38 | Miami (OH) (106) | 17 | Final | W | 21 |
| 4 | 2022-09-24 | Indiana (38) | 24 | Cincinnati (28) | 45 | Final | W | 21 |
| 5 | 2022-10-01 | Cincinnati (34) | 31 | Tulsa (92) | 21 | Final | W | 10 |
| 6 | 2022-10-08 | South Florida (127) | 24 | Cincinnati (36) | 28 | Final | W | 4 |
| 7 | 2022-10-22 | Cincinnati (30) | 29 | SMU (68) | 27 | Final | W | 2 |
| 8 | 2022-10-29 | Cincinnati (40) | 21 | Central Florida (26) | 25 | Final | L | -4 |
| 9 | 2022-11-05 | Navy (106) | 10 | Cincinnati (39) | 20 | Final | W | 10 |
| 10 | 2022-11-11 | East Carolina (50) | 25 | Cincinnati (29) | 27 | Final | W | 2 |
| 11 | 2022-11-19 | Cincinnati (28) | 23 | Temple (131) | 3 | Final | W | 20 |
| 12 | 2022-11-25 | Tulane (22) | 27 | Cincinnati (34) | 24 | Final | L | -3 |
| 13 | 2022-12-17 | Cincinnati (33) | 7 | Louisville (27) | 24 | Final | L | -17 |