Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Notre Dame (8) | 10 | Ohio State (4) | 21 | Final | W | 11 |
| 2 | 2022-09-10 | Arkansas State (151) | 12 | Ohio State (4) | 45 | Final | W | 33 |
| 3 | 2022-09-17 | Toledo (57) | 21 | Ohio State (1) | 77 | Final | W | 56 |
| 4 | 2022-09-24 | Wisconsin (71) | 21 | Ohio State (2) | 52 | Final | W | 31 |
| 5 | 2022-10-01 | Rutgers (60) | 10 | Ohio State (1) | 49 | Final | W | 39 |
| 6 | 2022-10-08 | Ohio State (1) | 49 | Michigan State (79) | 20 | Final | W | 29 |
| 7 | 2022-10-22 | Iowa (74) | 10 | Ohio State (4) | 54 | Final | W | 44 |
| 8 | 2022-10-29 | Ohio State (1) | 44 | Penn State (14) | 31 | Final | W | 13 |
| 9 | 2022-11-05 | Ohio State (2) | 21 | Northwestern (137) | 7 | Final | W | 14 |
| 10 | 2022-11-12 | Indiana (93) | 14 | Ohio State (2) | 56 | Final | W | 42 |
| 11 | 2022-11-19 | Ohio State (2) | 43 | Maryland (46) | 30 | Final | W | 13 |
| 12 | 2022-11-26 | Michigan (2) | 45 | Ohio State (4) | 23 | Final | L | -22 |
| 13 | 2022-12-31 | Ohio State (3) | 41 | Georgia (1) | 42 | Final | L | -1 |