Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-11-13 | Fairleigh Dickinson (314) | 54 | 91 | Villanova (2) | Final | W | 37 |
| 2 | 2015-11-17 | Nebraska (106) | 63 | 87 | Villanova (2) | Final | W | 24 |
| 3 | 2015-11-20 | East Tennessee State (205) | 51 | 86 | Villanova (2) | Final | W | 35 |
| 4 | 2015-11-22 | Akron (111) | 56 | 75 | Villanova (2) | Final | W | 19 |
| 5 | 2015-11-26 | Stanford (53) | 45 | 59 | Villanova (2) | Final | W | 14 |
| 6 | 2015-11-27 | Georgia Tech (105) | 52 | 69 | Villanova (2) | Final | W | 17 |
| 7 | 2015-12-01 | Villanova (2) | 86 | 72 | Saint Joseph's (167) | Final | W | 14 |
| 8 | 2015-12-07 | Oklahoma (14) | 78 | 55 | Villanova (2) | Final | L | -23 |
| 9 | 2015-12-13 | La Salle (232) | 47 | 76 | Villanova (4) | Final | W | 29 |
| 10 | 2015-12-19 | Villanova (7) | 75 | 86 | Virginia (15) | Final | L | -11 |
| 11 | 2015-12-22 | Delaware (224) | 48 | 78 | Villanova (16) | Final | W | 30 |
| 12 | 2015-12-28 | Penn (281) | 57 | 77 | Villanova (16) | Final | W | 20 |
| 13 | 2015-12-31 | Xavier (2) | 64 | 95 | Villanova (15) | Final | W | 31 |
| 14 | 2016-01-02 | Villanova (15) | 85 | 71 | Creighton (81) | Final | W | 14 |
| 15 | 2016-01-06 | Seton Hall (39) | 63 | 72 | Villanova (5) | Final | W | 9 |
| 16 | 2016-01-10 | Villanova (5) | 60 | 55 | Butler (25) | Final | W | 5 |
| 17 | 2016-01-13 | Marquette (68) | 68 | 83 | Villanova (5) | Final | W | 15 |
| 18 | 2016-01-16 | Villanova (5) | 55 | 50 | Georgetown (89) | Final | W | 5 |
| 19 | 2016-01-20 | Villanova (4) | 72 | 71 | Seton Hall (43) | Final | W | 1 |
| 20 | 2016-01-23 | Providence (28) | 0 | 0 | Villanova (4) | Postponed | - | - |
| 21 | 2016-01-24 | Providence (28) | 82 | 76 | Villanova (4) | Final/OT | L | -6 |
| 22 | 2016-01-31 | Villanova (2) | 68 | 53 | St. John's (208) | Final | W | 15 |
| 23 | 2016-02-03 | Creighton (58) | 58 | 83 | Villanova (3) | Final | W | 25 |
| 24 | 2016-02-06 | Villanova (3) | 72 | 60 | Providence (22) | Final | W | 12 |
| 25 | 2016-02-09 | Villanova (1) | 86 | 59 | DePaul (150) | Final | W | 27 |
| 26 | 2016-02-13 | St. John's (211) | 63 | 73 | Villanova (1) | Final | W | 10 |
| 27 | 2016-02-17 | Villanova (1) | 83 | 67 | Temple (68) | Final | W | 16 |
| 28 | 2016-02-20 | Butler (32) | 67 | 77 | Villanova (1) | Final | W | 10 |
| 29 | 2016-02-24 | Villanova (1) | 83 | 90 | Xavier (3) | Final | L | -7 |
| 30 | 2016-02-27 | Villanova (1) | 89 | 79 | Marquette (71) | Final | W | 10 |
| 31 | 2016-03-01 | DePaul (170) | 62 | 83 | Villanova (2) | Final | W | 21 |
| 32 | 2016-03-05 | Georgetown (80) | 71 | 84 | Villanova (2) | Final | W | 13 |
| 33 | 2016-03-10 | Georgetown (89) | 67 | 81 | Villanova (2) | Final | W | 14 |
| 34 | 2016-03-11 | Providence (35) | 68 | 76 | Villanova (2) | Final | W | 8 |
| 35 | 2016-03-12 | Seton Hall (27) | 69 | 67 | Villanova (2) | Final | L | -2 |
| 36 | 2016-03-18 | UNC-Asheville (133) | 56 | 86 | Villanova (2) | Final - 0:00 | W | 30 |
| 37 | 2016-03-20 | Iowa (25) | 68 | 87 | Villanova (2) | Final - 0:00 | W | 19 |
| 38 | 2016-03-24 | Miami (9) | 69 | 92 | Villanova (2) | Final - 0:00 | W | 23 |
| 39 | 2016-03-26 | Villanova (2) | 64 | 59 | Kansas (1) | Final - 0:00 | W | 5 |
| 40 | 2016-04-02 | Villanova (2) | 95 | 51 | Oklahoma (6) | Final - 0:00 | W | 44 |
| 41 | 2016-04-04 | Villanova (2) | 77 | 74 | North Carolina (4) | Final | W | 3 |