Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-11-13 | Gardner-Webb (194) | 59 | 76 | Iowa (29) | Final | W | 17 |
| 2 | 2015-11-15 | Coppin State (335) | 68 | 103 | Iowa (29) | Final | W | 35 |
| 3 | 2015-11-19 | Iowa (29) | 89 | 61 | Marquette (100) | Final | W | 28 |
| 4 | 2015-11-26 | Iowa (29) | 77 | 82 | Dayton (41) | Final | L | -5 |
| 5 | 2015-11-27 | Notre Dame (8) | 68 | 62 | Iowa (29) | Final | L | -6 |
| 6 | 2015-11-29 | Wichita State (17) | 61 | 84 | Iowa (29) | Final | W | 23 |
| 7 | 2015-12-02 | Florida State (85) | 75 | 78 | Iowa (29) | Final/OT | W | 3 |
| 8 | 2015-12-05 | UMKC (287) | 75 | 95 | Iowa (29) | Final | W | 20 |
| 9 | 2015-12-07 | Western Illinois (317) | 56 | 90 | Iowa (29) | Final | W | 34 |
| 10 | 2015-12-10 | Iowa (36) | 82 | 83 | Iowa State (5) | Final | L | -1 |
| 11 | 2015-12-19 | Drake (224) | 64 | 70 | Iowa (30) | Final | W | 6 |
| 12 | 2015-12-22 | Tennessee Tech (179) | 63 | 85 | Iowa (34) | Final | W | 22 |
| 13 | 2015-12-29 | Michigan State (1) | 70 | 83 | Iowa (32) | Final | W | 13 |
| 14 | 2016-01-02 | Iowa (32) | 70 | 63 | Purdue (5) | Final | W | 7 |
| 15 | 2016-01-05 | Nebraska (131) | 66 | 77 | Iowa (21) | Final | W | 11 |
| 16 | 2016-01-14 | Iowa (16) | 76 | 59 | Michigan State (3) | Final | W | 17 |
| 17 | 2016-01-17 | Michigan (30) | 71 | 82 | Iowa (16) | Final | W | 11 |
| 18 | 2016-01-21 | Iowa (8) | 90 | 76 | Rutgers (241) | Final | W | 14 |
| 19 | 2016-01-24 | Purdue (11) | 71 | 83 | Iowa (8) | Final | W | 12 |
| 20 | 2016-01-28 | Iowa (6) | 68 | 74 | Maryland (14) | Final | L | -6 |
| 21 | 2016-01-31 | Northwestern (60) | 71 | 85 | Iowa (6) | Final | W | 14 |
| 22 | 2016-02-03 | Penn State (119) | 49 | 73 | Iowa (6) | Final | W | 24 |
| 23 | 2016-02-07 | Iowa (6) | 77 | 65 | Illinois (116) | Final | W | 12 |
| 24 | 2016-02-11 | Iowa (5) | 78 | 85 | Indiana (25) | Final | L | -7 |
| 25 | 2016-02-14 | Minnesota (190) | 71 | 75 | Iowa (5) | Final | W | 4 |
| 26 | 2016-02-17 | Iowa (8) | 75 | 79 | Penn State (122) | Final | L | -4 |
| 27 | 2016-02-24 | Wisconsin (44) | 67 | 59 | Iowa (13) | Final | L | -8 |
| 28 | 2016-02-28 | Iowa (13) | 64 | 68 | Ohio State (62) | Final | L | -4 |
| 29 | 2016-03-01 | Indiana (16) | 81 | 78 | Iowa (22) | Final | L | -3 |
| 30 | 2016-03-05 | Iowa (22) | 71 | 61 | Michigan (41) | Final | W | 10 |
| 31 | 2016-03-10 | Illinois (123) | 68 | 66 | Iowa (22) | Final | L | -2 |
| 32 | 2016-03-18 | Temple (64) | 70 | 72 | Iowa (25) | Final (OT) - 0:00 | W | 2 |
| 33 | 2016-03-20 | Iowa (25) | 68 | 87 | Villanova (2) | Final - 0:00 | L | -19 |