Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-11-14 | Western Michigan (137) | 63 | 69 | DePaul (138) | Final | W | 6 |
| 2 | 2015-11-17 | DePaul (138) | 62 | 68 | Penn State (80) | Final | L | -6 |
| 3 | 2015-11-20 | DePaul (138) | 61 | 76 | South Carolina (71) | Final | L | -15 |
| 4 | 2015-11-21 | Florida State (85) | 83 | 67 | DePaul (138) | Final | L | -16 |
| 5 | 2015-11-23 | Norfolk State (198) | 78 | 82 | DePaul (138) | Final | W | 4 |
| 6 | 2015-12-02 | DePaul (138) | 82 | 55 | Illinois-Chicago (294) | Final | W | 27 |
| 7 | 2015-12-05 | Chicago State (331) | 72 | 96 | DePaul (138) | Final | W | 24 |
| 8 | 2015-12-09 | DePaul (164) | 74 | 71 | Drake (204) | Final | W | 3 |
| 9 | 2015-12-12 | Little Rock (34) | 66 | 44 | DePaul (164) | Final | L | -22 |
| 10 | 2015-12-15 | DePaul (154) | 60 | 79 | Stanford (94) | Final | L | -19 |
| 11 | 2015-12-19 | Northwestern (37) | 78 | 70 | DePaul (154) | Final/OT | L | -8 |
| 12 | 2015-12-22 | George Washington (19) | 61 | 82 | DePaul (182) | Final | W | 21 |
| 13 | 2015-12-30 | Georgetown (102) | 70 | 58 | DePaul (132) | Final | L | -12 |
| 14 | 2016-01-02 | DePaul (132) | 74 | 78 | Seton Hall (44) | Final | L | -4 |
| 15 | 2016-01-05 | Butler (25) | 77 | 72 | DePaul (151) | Final | L | -5 |
| 16 | 2016-01-09 | DePaul (151) | 63 | 74 | Georgetown (81) | Final | L | -11 |
| 17 | 2016-01-12 | DePaul (171) | 64 | 84 | Xavier (6) | Final | L | -20 |
| 18 | 2016-01-17 | Creighton (58) | 91 | 80 | DePaul (171) | Final | L | -11 |
| 19 | 2016-01-20 | DePaul (174) | 57 | 56 | Marquette (67) | Final | W | 1 |
| 20 | 2016-01-27 | DePaul (157) | 53 | 67 | Butler (29) | Final | L | -14 |
| 21 | 2016-01-30 | Xavier (3) | 86 | 65 | DePaul (157) | Final | L | -21 |
| 22 | 2016-02-02 | Providence (22) | 70 | 77 | DePaul (161) | Final | W | 7 |
| 23 | 2016-02-06 | DePaul (161) | 66 | 88 | Creighton (58) | Final | L | -22 |
| 24 | 2016-02-09 | Villanova (1) | 86 | 59 | DePaul (150) | Final | L | -27 |
| 25 | 2016-02-17 | DePaul (150) | 65 | 80 | St. John's (212) | Final | L | -15 |
| 26 | 2016-02-20 | Marquette (76) | 73 | 60 | DePaul (150) | Final | L | -13 |
| 27 | 2016-02-25 | St. John's (204) | 75 | 83 | DePaul (171) | Final | W | 8 |
| 28 | 2016-02-27 | DePaul (171) | 66 | 87 | Providence (38) | Final | L | -21 |
| 29 | 2016-03-01 | DePaul (170) | 62 | 83 | Villanova (2) | Final | L | -21 |
| 30 | 2016-03-05 | Seton Hall (27) | 80 | 66 | DePaul (170) | Final | L | -14 |
| 31 | 2016-03-09 | DePaul (170) | 53 | 70 | Georgetown (89) | Final | L | -17 |