Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-11-13 | Robert Morris (193) | 75 | 76 | Penn (275) | Final | W | 1 |
| 2 | 2015-11-15 | Central Connecticut State (343) | 61 | 77 | Penn (275) | Final | W | 16 |
| 3 | 2015-11-17 | Penn (275) | 60 | 54 | Delaware State (264) | Final | W | 6 |
| 4 | 2015-11-21 | Penn (275) | 67 | 104 | Washington (97) | Final | L | -37 |
| 5 | 2015-11-25 | La Salle (107) | 64 | 80 | Penn (275) | Final | W | 16 |
| 6 | 2015-11-29 | Penn (275) | 86 | 92 | Lafayette (160) | Final | L | -6 |
| 7 | 2015-12-02 | Navy (257) | 65 | 59 | Penn (275) | Final | L | -6 |
| 8 | 2015-12-05 | Penn (275) | 44 | 63 | George Mason (215) | Final | L | -19 |
| 9 | 2015-12-09 | Temple (139) | 77 | 73 | Penn (259) | Final | L | -4 |
| 10 | 2015-12-19 | Ursinus | 66 | 73 | Penn (273) | Final | W | 7 |
| 11 | 2015-12-22 | Penn (281) | 52 | 53 | Drexel (268) | Final/OT | L | -1 |
| 12 | 2015-12-28 | Penn (281) | 57 | 77 | Villanova (16) | Final | L | -20 |
| 13 | 2016-01-02 | Binghamton (316) | 45 | 80 | Penn (288) | Final | W | 35 |
| 14 | 2016-01-09 | Princeton (106) | 73 | 71 | Penn (275) | Final/OT | L | -2 |
| 15 | 2016-01-20 | Saint Joseph's (32) | 75 | 60 | Penn (263) | Final | L | -15 |
| 16 | 2016-01-29 | Penn (268) | 58 | 81 | Yale (110) | Final | L | -23 |
| 17 | 2016-01-30 | Penn (268) | 83 | 89 | Brown (297) | Final | L | -6 |
| 18 | 2016-02-05 | Dartmouth (258) | 64 | 71 | Penn (291) | Final | W | 7 |
| 19 | 2016-02-06 | Harvard (198) | 57 | 67 | Penn (291) | Final | W | 10 |
| 20 | 2016-02-12 | Penn (260) | 53 | 63 | Columbia (127) | Final | L | -10 |
| 21 | 2016-02-13 | Penn (260) | 92 | 84 | Cornell (234) | Final | W | 8 |
| 22 | 2016-02-19 | Brown (297) | 74 | 79 | Penn (256) | Final | W | 5 |
| 23 | 2016-02-20 | Yale (79) | 79 | 58 | Penn (256) | Final | L | -21 |
| 24 | 2016-02-26 | Cornell (266) | 67 | 79 | Penn (248) | Final | W | 12 |
| 25 | 2016-02-27 | Columbia (124) | 93 | 65 | Penn (248) | Final | L | -28 |
| 26 | 2016-03-04 | Penn (247) | 64 | 72 | Dartmouth (263) | Final | L | -8 |
| 27 | 2016-03-05 | Penn (247) | 56 | 74 | Harvard (224) | Final | L | -18 |
| 28 | 2016-03-08 | Penn (261) | 71 | 72 | Princeton (75) | Final | L | -1 |