Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-11-14 | Texas Southern (186) | 70 | 93 | Creighton (98) | Final | W | 23 |
| 2 | 2015-11-17 | UTSA (230) | 78 | 103 | Creighton (98) | Final | W | 25 |
| 3 | 2015-11-19 | Creighton (98) | 65 | 86 | Indiana (38) | Final | L | -21 |
| 4 | 2015-11-23 | Rutgers (161) | 75 | 85 | Creighton (98) | Final | W | 10 |
| 5 | 2015-11-25 | Massachusetts (103) | 76 | 97 | Creighton (98) | Final | W | 21 |
| 6 | 2015-11-28 | Western Illinois (317) | 67 | 97 | Creighton (98) | Final | W | 30 |
| 7 | 2015-12-02 | Arizona State (74) | 79 | 77 | Creighton (98) | Final | L | -2 |
| 8 | 2015-12-05 | Creighton (98) | 65 | 68 | Loyola-Chicago (132) | Final | L | -3 |
| 9 | 2015-12-09 | Nebraska (81) | 67 | 83 | Creighton (88) | Final | W | 16 |
| 10 | 2015-12-12 | IUPUI (276) | 65 | 90 | Creighton (88) | Final | W | 25 |
| 11 | 2015-12-19 | Creighton (76) | 74 | 87 | Oklahoma (4) | Final | L | -13 |
| 12 | 2015-12-21 | North Texas (313) | 82 | 105 | Creighton (76) | Final | W | 23 |
| 13 | 2015-12-28 | Coppin State (344) | 77 | 102 | Creighton (87) | Final | W | 25 |
| 14 | 2015-12-31 | Creighton (81) | 80 | 70 | St. John's (192) | Final | W | 10 |
| 15 | 2016-01-02 | Villanova (15) | 85 | 71 | Creighton (81) | Final | L | -14 |
| 16 | 2016-01-05 | Georgetown (81) | 66 | 79 | Creighton (77) | Final | W | 13 |
| 17 | 2016-01-09 | Creighton (77) | 82 | 67 | Seton Hall (39) | Final | W | 15 |
| 18 | 2016-01-12 | Providence (22) | 50 | 48 | Creighton (58) | Final | L | -2 |
| 19 | 2016-01-17 | Creighton (58) | 91 | 80 | DePaul (171) | Final | W | 11 |
| 20 | 2016-01-23 | Butler (23) | 64 | 72 | Creighton (56) | Final | W | 8 |
| 21 | 2016-01-26 | Creighton (50) | 73 | 74 | Georgetown (70) | Final | L | -1 |
| 22 | 2016-01-30 | Seton Hall (47) | 75 | 65 | Creighton (50) | Final | L | -10 |
| 23 | 2016-02-03 | Creighton (58) | 58 | 83 | Villanova (3) | Final | L | -25 |
| 24 | 2016-02-06 | DePaul (161) | 66 | 88 | Creighton (58) | Final | W | 22 |
| 25 | 2016-02-09 | Xavier (2) | 56 | 70 | Creighton (61) | Final | W | 14 |
| 26 | 2016-02-13 | Creighton (61) | 65 | 62 | Marquette (72) | Final | W | 3 |
| 27 | 2016-02-16 | Creighton (49) | 75 | 88 | Butler (32) | Final | L | -13 |
| 28 | 2016-02-24 | Marquette (71) | 66 | 61 | Creighton (52) | Final | L | -5 |
| 29 | 2016-02-28 | St. John's (204) | 59 | 100 | Creighton (52) | Final | W | 41 |
| 30 | 2016-03-02 | Creighton (52) | 66 | 70 | Providence (42) | Final | L | -4 |
| 31 | 2016-03-05 | Creighton (52) | 93 | 98 | Xavier (3) | Final | L | -5 |
| 32 | 2016-03-10 | Creighton (57) | 73 | 81 | Seton Hall (27) | Final | L | -8 |
| 33 | 2016-03-15 | Alabama (80) | 54 | 72 | Creighton (59) | Final | W | 18 |
| 34 | 2016-03-19 | Wagner (192) | 54 | 87 | Creighton (59) | Final | W | 33 |
| 35 | 2016-03-22 | Creighton (59) | 82 | 88 | BYU (72) | Final | L | -6 |