Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-11-13 | Samford (286) | 45 | 86 | Louisville (12) | Final | W | 41 |
| 2 | 2015-11-17 | Hartford (263) | 52 | 87 | Louisville (12) | Final | W | 35 |
| 3 | 2015-11-21 | North Florida (149) | 61 | 89 | Louisville (12) | Final | W | 28 |
| 4 | 2015-11-24 | St. Francis (NY) (157) | 41 | 85 | Louisville (12) | Final | W | 44 |
| 5 | 2015-11-28 | Saint Louis (239) | 57 | 77 | Louisville (12) | Final | W | 20 |
| 6 | 2015-12-02 | Louisville (12) | 67 | 71 | Michigan State (21) | Final | L | -4 |
| 7 | 2015-12-05 | Grand Canyon (243) | 63 | 111 | Louisville (12) | Final | W | 48 |
| 8 | 2015-12-12 | Eastern Michigan (168) | 53 | 86 | Louisville (8) | Final | W | 33 |
| 9 | 2015-12-16 | Kennesaw State (305) | 57 | 94 | Louisville (6) | Final | W | 37 |
| 10 | 2015-12-19 | Western Kentucky (162) | 56 | 78 | Louisville (6) | Final | W | 22 |
| 11 | 2015-12-22 | UMKC (198) | 47 | 75 | Louisville (5) | Final | W | 28 |
| 12 | 2015-12-23 | Utah Valley (285) | 68 | 98 | Louisville (5) | Final | W | 30 |
| 13 | 2015-12-26 | Louisville (5) | 73 | 75 | Kentucky (33) | Final | L | -2 |
| 14 | 2016-01-03 | Wake Forest (69) | 57 | 65 | Louisville (11) | Final | W | 8 |
| 15 | 2016-01-07 | Louisville (13) | 77 | 72 | North Carolina State (75) | Final | W | 5 |
| 16 | 2016-01-10 | Louisville (13) | 62 | 66 | Clemson (122) | Final | L | -4 |
| 17 | 2016-01-14 | Pittsburgh (10) | 41 | 59 | Louisville (17) | Final | W | 18 |
| 18 | 2016-01-20 | Florida State (47) | 65 | 84 | Louisville (14) | Final | W | 19 |
| 19 | 2016-01-23 | Louisville (14) | 75 | 71 | Georgia Tech (59) | Final | W | 4 |
| 20 | 2016-01-27 | Louisville (11) | 91 | 83 | Virginia Tech (78) | Final | W | 8 |
| 21 | 2016-01-30 | Virginia (16) | 63 | 47 | Louisville (11) | Final | L | -16 |
| 22 | 2016-02-01 | North Carolina (5) | 65 | 71 | Louisville (11) | Final | W | 6 |
| 23 | 2016-02-06 | Boston College (201) | 47 | 79 | Louisville (15) | Final | W | 32 |
| 24 | 2016-02-08 | Louisville (15) | 65 | 72 | Duke (23) | Final | L | -7 |
| 25 | 2016-02-13 | Louisville (11) | 66 | 71 | Notre Dame (31) | Final | L | -5 |
| 26 | 2016-02-17 | Syracuse (38) | 58 | 72 | Louisville (16) | Final | W | 14 |
| 27 | 2016-02-20 | Duke (13) | 64 | 71 | Louisville (16) | Final | W | 7 |
| 28 | 2016-02-24 | Louisville (9) | 67 | 60 | Pittsburgh (25) | Final | W | 7 |
| 29 | 2016-02-27 | Louisville (9) | 65 | 73 | Miami (10) | Final | L | -8 |
| 30 | 2016-03-01 | Georgia Tech (57) | 53 | 56 | Louisville (10) | Final | W | 3 |
| 31 | 2016-03-05 | Louisville (10) | 46 | 68 | Virginia (7) | Final | L | -22 |