Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-11-13 | Florida Atlantic (297) | 55 | 82 | Michigan State (21) | Final | W | 27 |
| 2 | 2015-11-17 | Kansas (9) | 73 | 79 | Michigan State (21) | Final | W | 6 |
| 3 | 2015-11-20 | Arkansas-Pine Bluff (322) | 46 | 92 | Michigan State (21) | Final | W | 46 |
| 4 | 2015-11-23 | Eastern Michigan (129) | 65 | 89 | Michigan State (21) | Final | W | 24 |
| 5 | 2015-11-26 | Boston College (104) | 68 | 99 | Michigan State (21) | Final | W | 31 |
| 6 | 2015-11-27 | Boise State (51) | 67 | 77 | Michigan State (21) | Final | W | 10 |
| 7 | 2015-11-29 | Michigan State (21) | 77 | 64 | Providence (26) | Final | W | 13 |
| 8 | 2015-12-02 | Louisville (12) | 67 | 71 | Michigan State (21) | Final | W | 4 |
| 9 | 2015-12-05 | Binghamton (332) | 33 | 76 | Michigan State (21) | Final | W | 43 |
| 10 | 2015-12-09 | Maryland-Eastern Shore (333) | 35 | 78 | Michigan State (1) | Final | W | 43 |
| 11 | 2015-12-12 | Florida (10) | 52 | 58 | Michigan State (1) | Final | W | 6 |
| 12 | 2015-12-19 | Michigan State (1) | 78 | 58 | Northeastern (123) | Final | W | 20 |
| 13 | 2015-12-22 | Michigan State (1) | 99 | 93 | Oakland (91) | Final/OT | W | 6 |
| 14 | 2015-12-29 | Michigan State (1) | 70 | 83 | Iowa (32) | Final | L | -13 |
| 15 | 2016-01-02 | Michigan State (1) | 69 | 61 | Minnesota (161) | Final | W | 8 |
| 16 | 2016-01-07 | Illinois (111) | 54 | 79 | Michigan State (2) | Final | W | 25 |
| 17 | 2016-01-10 | Michigan State (2) | 92 | 65 | Penn State (115) | Final | W | 27 |
| 18 | 2016-01-14 | Iowa (16) | 76 | 59 | Michigan State (3) | Final | L | -17 |
| 19 | 2016-01-17 | Michigan State (3) | 76 | 77 | Wisconsin (88) | Final | L | -1 |
| 20 | 2016-01-20 | Nebraska (100) | 72 | 71 | Michigan State (9) | Final | L | -1 |
| 21 | 2016-01-23 | Maryland (13) | 65 | 74 | Michigan State (9) | Final | W | 9 |
| 22 | 2016-01-28 | Michigan State (10) | 76 | 45 | Northwestern (60) | Final | W | 31 |
| 23 | 2016-01-31 | Rutgers (244) | 62 | 96 | Michigan State (10) | Final | W | 34 |
| 24 | 2016-02-06 | Michigan State (7) | 89 | 73 | Michigan (25) | Final | W | 16 |
| 25 | 2016-02-09 | Michigan State (6) | 81 | 82 | Purdue (17) | Final/OT | L | -1 |
| 26 | 2016-02-14 | Indiana (25) | 69 | 88 | Michigan State (6) | Final | W | 19 |
| 27 | 2016-02-18 | Wisconsin (43) | 57 | 69 | Michigan State (6) | Final | W | 12 |
| 28 | 2016-02-23 | Michigan State (5) | 81 | 62 | Ohio State (62) | Final | W | 19 |
| 29 | 2016-02-28 | Penn State (111) | 57 | 88 | Michigan State (5) | Final | W | 31 |
| 30 | 2016-03-02 | Michigan State (4) | 97 | 66 | Rutgers (286) | Final | W | 31 |
| 31 | 2016-03-05 | Ohio State (60) | 76 | 91 | Michigan State (4) | Final | W | 15 |
| 32 | 2016-03-11 | Ohio State (61) | 54 | 81 | Michigan State (3) | Final | W | 27 |
| 33 | 2016-03-12 | Maryland (21) | 61 | 64 | Michigan State (3) | Final | W | 3 |
| 34 | 2016-03-13 | Purdue (14) | 62 | 66 | Michigan State (3) | Final | W | 4 |
| 35 | 2016-03-18 | Middle Tennessee (113) | 90 | 81 | Michigan State (3) | Final - 0:00 | L | -9 |