Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-11-13 | North Carolina Central (110) | 40 | 74 | Clemson (76) | Final | W | 34 |
| 2 | 2015-11-15 | UTSA (230) | 45 | 78 | Clemson (76) | Final | W | 33 |
| 3 | 2015-11-19 | Texas Southern (186) | 56 | 76 | Clemson (76) | Final | W | 20 |
| 4 | 2015-11-23 | Massachusetts (103) | 82 | 65 | Clemson (76) | Final | L | -17 |
| 5 | 2015-11-25 | Clemson (76) | 76 | 58 | Rutgers (161) | Final | W | 18 |
| 6 | 2015-11-30 | Clemson (76) | 83 | 89 | Minnesota (57) | Final | L | -6 |
| 7 | 2015-12-02 | South Carolina Upstate (159) | 56 | 76 | Clemson (76) | Final | W | 20 |
| 8 | 2015-12-06 | Wofford (75) | 51 | 66 | Clemson (76) | Final | W | 15 |
| 9 | 2015-12-13 | Alabama (78) | 51 | 50 | Clemson (102) | Final | L | -1 |
| 10 | 2015-12-15 | Presbyterian (285) | 41 | 69 | Clemson (134) | Final | W | 28 |
| 11 | 2015-12-18 | South Carolina (12) | 65 | 59 | Clemson (134) | Final | L | -6 |
| 12 | 2015-12-22 | Clemson (122) | 48 | 71 | Georgia (71) | Final | L | -23 |
| 13 | 2015-12-30 | Clemson (146) | 69 | 80 | North Carolina (17) | Final | L | -11 |
| 14 | 2016-01-02 | Florida State (59) | 75 | 84 | Clemson (146) | Final | W | 9 |
| 15 | 2016-01-05 | Clemson (122) | 74 | 73 | Syracuse (70) | Final/OT | W | 1 |
| 16 | 2016-01-10 | Louisville (13) | 62 | 66 | Clemson (122) | Final | W | 4 |
| 17 | 2016-01-13 | Duke (11) | 63 | 68 | Clemson (94) | Final | W | 5 |
| 18 | 2016-01-16 | Miami (8) | 65 | 76 | Clemson (94) | Final | W | 11 |
| 19 | 2016-01-19 | Clemson (57) | 62 | 69 | Virginia (18) | Final | L | -7 |
| 20 | 2016-01-27 | Pittsburgh (18) | 60 | 73 | Clemson (65) | Final | W | 13 |
| 21 | 2016-01-30 | Clemson (65) | 65 | 76 | Florida State (52) | Final | L | -11 |
| 22 | 2016-02-02 | Clemson (54) | 76 | 62 | Wake Forest (101) | Final | W | 14 |
| 23 | 2016-02-06 | Clemson (54) | 57 | 60 | Virginia Tech (89) | Final | L | -3 |
| 24 | 2016-02-08 | Notre Dame (37) | 89 | 83 | Clemson (54) | Final | L | -6 |
| 25 | 2016-02-13 | Georgia Tech (67) | 52 | 66 | Clemson (56) | Final | W | 14 |
| 26 | 2016-02-17 | Boston College (206) | 54 | 65 | Clemson (55) | Final | W | 11 |
| 27 | 2016-02-20 | Clemson (55) | 74 | 77 | North Carolina State (83) | Final | L | -3 |
| 28 | 2016-02-23 | Clemson (60) | 73 | 75 | Georgia Tech (59) | Final | L | -2 |
| 29 | 2016-03-01 | Virginia (7) | 64 | 57 | Clemson (66) | Final | L | -7 |
| 30 | 2016-03-05 | Clemson (66) | 66 | 50 | Boston College (225) | Final | W | 16 |
| 31 | 2016-03-09 | Georgia Tech (52) | 88 | 85 | Clemson (65) | Final/OT | L | -3 |