Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-11-13 | Siena (267) | 74 | 92 | Duke (4) | Final | W | 18 |
| 2 | 2015-11-14 | Bryant (220) | 75 | 113 | Duke (4) | Final | W | 38 |
| 3 | 2015-11-17 | Kentucky (1) | 74 | 63 | Duke (4) | Final | L | -11 |
| 4 | 2015-11-20 | Duke (4) | 79 | 71 | Virginia Commonwealth (27) | Final | W | 8 |
| 5 | 2015-11-22 | Duke (4) | 86 | 84 | Georgetown (24) | Final | W | 2 |
| 6 | 2015-11-25 | Yale (99) | 61 | 80 | Duke (4) | Final | W | 19 |
| 7 | 2015-11-29 | Utah State (128) | 52 | 85 | Duke (4) | Final | W | 33 |
| 8 | 2015-12-02 | Indiana (38) | 74 | 94 | Duke (4) | Final | W | 20 |
| 9 | 2015-12-05 | Buffalo (60) | 59 | 82 | Duke (4) | Final | W | 23 |
| 10 | 2015-12-15 | Georgia Southern (256) | 65 | 99 | Duke (14) | Final | W | 34 |
| 11 | 2015-12-19 | Utah (47) | 77 | 75 | Duke (14) | Final/OT | L | -2 |
| 12 | 2015-12-28 | Elon (147) | 66 | 105 | Duke (25) | Final | W | 39 |
| 13 | 2015-12-30 | Long Beach State (159) | 81 | 103 | Duke (20) | Final | W | 22 |
| 14 | 2016-01-02 | Duke (20) | 81 | 64 | Boston College (176) | Final | W | 17 |
| 15 | 2016-01-06 | Duke (18) | 91 | 75 | Wake Forest (68) | Final | W | 16 |
| 16 | 2016-01-09 | Virginia Tech (84) | 58 | 82 | Duke (18) | Final | W | 24 |
| 17 | 2016-01-13 | Duke (11) | 63 | 68 | Clemson (94) | Final | L | -5 |
| 18 | 2016-01-16 | Notre Dame (50) | 95 | 91 | Duke (11) | Final | L | -4 |
| 19 | 2016-01-18 | Syracuse (84) | 64 | 62 | Duke (11) | Final | L | -2 |
| 20 | 2016-01-23 | Duke (19) | 88 | 78 | North Carolina State (96) | Final | W | 10 |
| 21 | 2016-01-25 | Duke (19) | 69 | 80 | Miami (15) | Final | L | -11 |
| 22 | 2016-02-02 | Duke (23) | 80 | 71 | Georgia Tech (57) | Final | W | 9 |
| 23 | 2016-02-06 | North Carolina State (77) | 80 | 88 | Duke (23) | Final | W | 8 |
| 24 | 2016-02-08 | Louisville (15) | 65 | 72 | Duke (23) | Final | W | 7 |
| 25 | 2016-02-13 | Virginia (9) | 62 | 63 | Duke (20) | Final | W | 1 |
| 26 | 2016-02-17 | Duke (13) | 74 | 73 | North Carolina (7) | Final | W | 1 |
| 27 | 2016-02-20 | Duke (13) | 64 | 71 | Louisville (16) | Final | L | -7 |
| 28 | 2016-02-25 | Florida State (56) | 65 | 80 | Duke (11) | Final | W | 15 |
| 29 | 2016-02-28 | Duke (11) | 62 | 76 | Pittsburgh (25) | Final | L | -14 |
| 30 | 2016-03-01 | Wake Forest (116) | 71 | 79 | Duke (12) | Final | W | 8 |
| 31 | 2016-03-05 | North Carolina (9) | 76 | 72 | Duke (12) | Final | L | -4 |
| 32 | 2016-03-09 | North Carolina State (90) | 89 | 92 | Duke (16) | Final | W | 3 |
| 33 | 2016-03-10 | Duke (16) | 79 | 84 | Notre Dame (32) | Final/OT | L | -5 |
| 34 | 2016-03-17 | UNC-Wilmington (77) | 85 | 93 | Duke (18) | Final - 0:00 | W | 8 |
| 35 | 2016-03-19 | Yale (68) | 64 | 71 | Duke (18) | Final - 0:00 | W | 7 |
| 36 | 2016-03-24 | Duke (18) | 68 | 82 | Oregon (10) | Final - 0:00 | L | -14 |