Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-11-13 | North Carolina A&T (341) | 40 | 81 | Purdue (36) | Final | W | 41 |
| 2 | 2015-11-15 | Vermont (165) | 79 | 107 | Purdue (36) | Final | W | 28 |
| 3 | 2015-11-18 | Incarnate Word (204) | 61 | 96 | Purdue (36) | Final | W | 35 |
| 4 | 2015-11-21 | Purdue (36) | 61 | 39 | Old Dominion (61) | Final | W | 22 |
| 5 | 2015-11-22 | Florida (55) | 70 | 85 | Purdue (36) | Final | W | 15 |
| 6 | 2015-11-28 | Lehigh (190) | 55 | 77 | Purdue (36) | Final | W | 22 |
| 7 | 2015-12-01 | Purdue (36) | 72 | 59 | Pittsburgh (65) | Final | W | 13 |
| 8 | 2015-12-05 | New Mexico (144) | 58 | 70 | Purdue (36) | Final | W | 12 |
| 9 | 2015-12-07 | IUPUI (280) | 53 | 80 | Purdue (36) | Final | W | 27 |
| 10 | 2015-12-09 | Howard (215) | 55 | 93 | Purdue (2) | Final | W | 38 |
| 11 | 2015-12-12 | Youngstown State (254) | 64 | 95 | Purdue (2) | Final | W | 31 |
| 12 | 2015-12-19 | Butler (16) | 74 | 68 | Purdue (3) | Final | L | -6 |
| 13 | 2015-12-22 | Vanderbilt (27) | 55 | 68 | Purdue (4) | Final | W | 13 |
| 14 | 2015-12-29 | Purdue (5) | 61 | 55 | Wisconsin (87) | Final | W | 6 |
| 15 | 2016-01-02 | Iowa (32) | 70 | 63 | Purdue (5) | Final | L | -7 |
| 16 | 2016-01-07 | Michigan (27) | 70 | 87 | Purdue (10) | Final | W | 17 |
| 17 | 2016-01-10 | Purdue (10) | 70 | 84 | Illinois (111) | Final | L | -14 |
| 18 | 2016-01-13 | Penn State (119) | 57 | 74 | Purdue (14) | Final | W | 17 |
| 19 | 2016-01-18 | Purdue (14) | 107 | 57 | Rutgers (235) | Final | W | 50 |
| 20 | 2016-01-21 | Ohio State (72) | 64 | 75 | Purdue (11) | Final | W | 11 |
| 21 | 2016-01-24 | Purdue (11) | 71 | 83 | Iowa (8) | Final | L | -12 |
| 22 | 2016-01-27 | Purdue (12) | 68 | 64 | Minnesota (188) | Final | W | 4 |
| 23 | 2016-01-30 | Nebraska (90) | 74 | 89 | Purdue (12) | Final | W | 15 |
| 24 | 2016-02-06 | Purdue (13) | 61 | 72 | Maryland (10) | Final | L | -11 |
| 25 | 2016-02-09 | Michigan State (6) | 81 | 82 | Purdue (17) | Final/OT | W | 1 |
| 26 | 2016-02-13 | Purdue (17) | 56 | 61 | Michigan (33) | Final | L | -5 |
| 27 | 2016-02-16 | Northwestern (71) | 61 | 71 | Purdue (15) | Final | W | 10 |
| 28 | 2016-02-20 | Purdue (15) | 73 | 77 | Indiana (21) | Final | L | -4 |
| 29 | 2016-02-27 | Maryland (14) | 79 | 83 | Purdue (16) | Final | W | 4 |
| 30 | 2016-03-01 | Purdue (15) | 81 | 62 | Nebraska (102) | Final | W | 19 |
| 31 | 2016-03-06 | Wisconsin (35) | 80 | 91 | Purdue (15) | Final | W | 11 |
| 32 | 2016-03-11 | Illinois (123) | 58 | 89 | Purdue (14) | Final | W | 31 |
| 33 | 2016-03-12 | Michigan (45) | 59 | 76 | Purdue (14) | Final | W | 17 |
| 34 | 2016-03-13 | Purdue (14) | 62 | 66 | Michigan State (3) | Final | L | -4 |
| 35 | 2016-03-17 | Little Rock (53) | 85 | 83 | Purdue (12) | Final (2OT) - 0:00 | L | -2 |