Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-11-13 | Colorado (93) | 62 | 68 | Iowa State (11) | Final | W | 6 |
| 2 | 2015-11-16 | Chicago State (331) | 64 | 106 | Iowa State (11) | Final | W | 42 |
| 3 | 2015-11-23 | Chattanooga (130) | 63 | 83 | Iowa State (11) | Final | W | 20 |
| 4 | 2015-11-27 | Virginia Tech (170) | 77 | 99 | Iowa State (11) | Final | W | 22 |
| 5 | 2015-11-28 | Iowa State (11) | 84 | 73 | Illinois (46) | Final | W | 11 |
| 6 | 2015-12-01 | North Dakota State (147) | 64 | 84 | Iowa State (11) | Final | W | 20 |
| 7 | 2015-12-07 | Buffalo (60) | 63 | 84 | Iowa State (11) | Final | W | 21 |
| 8 | 2015-12-10 | Iowa (36) | 82 | 83 | Iowa State (5) | Final | W | 1 |
| 9 | 2015-12-13 | Arkansas-Pine Bluff (308) | 64 | 78 | Iowa State (5) | Final | W | 14 |
| 10 | 2015-12-19 | Northern Iowa (99) | 81 | 79 | Iowa State (5) | Final | L | -2 |
| 11 | 2015-12-22 | Iowa State (13) | 81 | 79 | Cincinnati (20) | Final | W | 2 |
| 12 | 2015-12-30 | Coppin State (343) | 84 | 104 | Iowa State (13) | Final | W | 20 |
| 13 | 2016-01-02 | Iowa State (13) | 83 | 87 | Oklahoma (3) | Final | L | -4 |
| 14 | 2016-01-06 | Texas Tech (19) | 69 | 76 | Iowa State (17) | Final | W | 7 |
| 15 | 2016-01-09 | Baylor (54) | 94 | 89 | Iowa State (17) | Final | L | -5 |
| 16 | 2016-01-12 | Iowa State (19) | 91 | 94 | Texas (48) | Final/OT | L | -3 |
| 17 | 2016-01-16 | Iowa State (19) | 76 | 63 | Kansas State (55) | Final | W | 13 |
| 18 | 2016-01-18 | Oklahoma (2) | 77 | 82 | Iowa State (19) | Final | W | 5 |
| 19 | 2016-01-23 | Iowa State (20) | 73 | 60 | TCU (126) | Final | W | 13 |
| 20 | 2016-01-25 | Kansas (5) | 72 | 85 | Iowa State (20) | Final | W | 13 |
| 21 | 2016-01-30 | Iowa State (13) | 62 | 72 | Texas A&M (8) | Final | L | -10 |
| 22 | 2016-02-02 | West Virginia (11) | 81 | 76 | Iowa State (14) | Final | L | -5 |
| 23 | 2016-02-06 | Iowa State (14) | 64 | 59 | Oklahoma State (91) | Final | W | 5 |
| 24 | 2016-02-10 | Iowa State (16) | 82 | 85 | Texas Tech (53) | Final/OT | L | -3 |
| 25 | 2016-02-13 | Texas (22) | 75 | 85 | Iowa State (16) | Final | W | 10 |
| 26 | 2016-02-16 | Iowa State (17) | 91 | 100 | Baylor (25) | Final/OT | L | -9 |
| 27 | 2016-02-20 | TCU (117) | 83 | 92 | Iowa State (17) | Final | W | 9 |
| 28 | 2016-02-22 | Iowa State (17) | 87 | 97 | West Virginia (5) | Final | L | -10 |
| 29 | 2016-02-27 | Kansas State (53) | 61 | 80 | Iowa State (19) | Final | W | 19 |
| 30 | 2016-02-29 | Oklahoma State (101) | 50 | 58 | Iowa State (19) | Final | W | 8 |
| 31 | 2016-03-05 | Iowa State (18) | 78 | 85 | Kansas (1) | Final | L | -7 |
| 32 | 2016-03-10 | Iowa State (19) | 76 | 79 | Oklahoma (5) | Final | L | -3 |
| 33 | 2016-03-17 | Iona (106) | 81 | 94 | Iowa State (21) | Final - 0:00 | W | 13 |
| 34 | 2016-03-19 | Little Rock (53) | 61 | 78 | Iowa State (21) | Final - 0:00 | W | 17 |
| 35 | 2016-03-25 | Iowa State (21) | 71 | 84 | Virginia (8) | Final - 0:00 | L | -13 |