Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | South Dakota (275) | 61 | 84 | Colorado (73) | Final | L | -23 |
| 2 | 2020-11-27 | South Dakota (275) | 53 | 69 | Drake (217) | Final | L | -16 |
| 3 | 2020-11-27 | South Dakota (184) | 54 | 69 | Drake (149) | Final | L | -15 |
| 4 | 2020-12-01 | South Dakota (275) | 69 | 76 | Nebraska (13) | Final | L | -7 |
| 5 | 2020-12-05 | UMKC (364) | 0 | 0 | South Dakota (275) | Cancelled | - | - |
| 6 | 2020-12-05 | South Dakota (324) | 0 | 0 | UMKC (258) | Cancelled | - | - |
| 7 | 2020-12-10 | North Dakota (251) | 75 | 71 | South Dakota (275) | Final | L | -4 |
| 8 | 2020-12-11 | South Dakota (275) | 67 | 74 | North Dakota State (117) | Final | L | -7 |
| 9 | 2020-12-12 | South Dakota (275) | 91 | 78 | South Dakota State (268) | Final | W | 13 |
| 10 | 2020-12-16 | Drake (217) | 0 | 0 | South Dakota (275) | Postponed | - | - |
| 11 | 2020-12-18 | Drake (217) | 75 | 57 | South Dakota (275) | Final | L | -18 |
| 12 | 2020-12-20 | Mount Marty College | 44 | 84 | South Dakota (311) | Final | W | 40 |
| 13 | 2021-01-02 | Denver (253) | 54 | 93 | South Dakota (275) | Final | W | 39 |
| 14 | 2021-01-03 | Denver (253) | 57 | 79 | South Dakota (275) | Final | W | 22 |
| 15 | 2021-01-08 | South Dakota (275) | 66 | 64 | UMKC (364) | Final | W | 2 |
| 16 | 2021-01-09 | South Dakota (275) | 68 | 62 | UMKC (364) | Final | W | 6 |
| 17 | 2021-01-22 | South Dakota (275) | 65 | 60 | Western Illinois (362) | Final | W | 5 |
| 18 | 2021-01-23 | South Dakota (275) | 84 | 74 | Western Illinois (362) | Final | W | 10 |
| 19 | 2021-01-29 | Nebraska-Omaha (272) | 59 | 91 | South Dakota (275) | Final | W | 32 |
| 20 | 2021-01-30 | Nebraska-Omaha (272) | 93 | 97 | South Dakota (275) | Final | W | 4 |
| 21 | 2021-02-05 | South Dakota (275) | 64 | 56 | South Dakota State (268) | Final | W | 8 |
| 22 | 2021-02-06 | South Dakota (275) | 78 | 89 | South Dakota State (268) | Final | L | -11 |
| 23 | 2021-02-13 | South Dakota (275) | 76 | 85 | North Dakota (251) | Final | L | -9 |
| 24 | 2021-02-14 | South Dakota (275) | 81 | 85 | North Dakota (251) | Final | L | -4 |
| 25 | 2021-02-20 | Oral Roberts (327) | 84 | 86 | South Dakota (275) | Final | W | 2 |
| 26 | 2021-02-21 | Oral Roberts (327) | 0 | 0 | South Dakota (275) | Cancelled | - | - |
| 27 | 2021-02-27 | North Dakota State (117) | 71 | 80 | South Dakota (275) | Final | W | 9 |
| 28 | 2021-02-28 | North Dakota State (117) | 89 | 77 | South Dakota (275) | Final | L | -12 |
| 29 | 2021-03-06 | Western Illinois (362) | 69 | 86 | South Dakota (275) | Final | W | 17 |
| 30 | 2021-03-08 | North Dakota State (188) | 79 | 75 | South Dakota (193) | Final | L | -4 |