Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2024-11-04 | Texas A&M-Corpus Christi (208) | 73 | 90 | Purdue (8) | Final | W | 17 |
| 2 | 2024-11-08 | Northern Kentucky (343) | 50 | 72 | Purdue (28) | Final | W | 22 |
| 3 | 2024-11-11 | Yale (200) | 84 | 92 | Purdue (17) | Final | W | 8 |
| 4 | 2024-11-15 | Alabama (79) | 78 | 87 | Purdue (14) | Final | W | 9 |
| 5 | 2024-11-19 | Purdue (49) | 58 | 76 | Marquette (3) | Final | L | -18 |
| 6 | 2024-11-23 | Marshall (155) | 45 | 80 | Purdue (8) | Final | W | 35 |
| 7 | 2024-11-28 | North Carolina State (70) | 61 | 71 | Purdue (16) | Final | W | 10 |
| 8 | 2024-11-29 | Ole Miss (37) | 78 | 80 | Purdue (11) | Final | W | 2 |
| 9 | 2024-12-05 | Purdue (28) | 70 | 81 | Penn State (21) | Final | L | -11 |
| 10 | 2024-12-08 | Maryland (31) | 78 | 83 | Purdue (14) | Final | W | 5 |
| 11 | 2024-12-14 | Texas A&M (15) | 70 | 66 | Purdue (26) | Final | L | -4 |
| 12 | 2024-12-21 | Purdue (29) | 69 | 87 | Auburn (1) | Final | L | -18 |
| 13 | 2024-12-29 | Toledo (196) | 64 | 83 | Purdue (30) | Final | W | 19 |
| 14 | 2025-01-02 | Purdue (26) | 81 | 61 | Minnesota (123) | Final | W | 20 |
| 15 | 2025-01-05 | Northwestern (64) | 61 | 79 | Purdue (25) | Final | W | 18 |
| 16 | 2025-01-09 | Purdue (20) | 68 | 50 | Rutgers (90) | Final | W | 18 |
| 17 | 2025-01-12 | Nebraska (37) | 68 | 104 | Purdue (14) | Final | W | 36 |
| 18 | 2025-01-15 | Purdue (16) | 69 | 58 | Washington (89) | Final | W | 11 |
| 19 | 2025-01-18 | Purdue (9) | 65 | 58 | Oregon (17) | Final | W | 7 |
| 20 | 2025-01-21 | Ohio State (37) | 73 | 70 | Purdue (15) | Final | L | -3 |
| 21 | 2025-01-24 | Michigan (23) | 64 | 91 | Purdue (10) | Final | W | 27 |
| 22 | 2025-01-31 | Indiana (50) | 76 | 81 | Purdue (9) | Final | W | 5 |
| 23 | 2025-02-04 | Purdue (7) | 90 | 81 | Iowa (59) | Final | W | 9 |
| 24 | 2025-02-07 | USC (60) | 72 | 90 | Purdue (7) | Final | W | 18 |
| 25 | 2025-02-11 | Purdue (8) | 73 | 75 | Michigan (11) | Final | L | -2 |
| 26 | 2025-02-15 | Wisconsin (12) | 94 | 84 | Purdue (9) | Final | L | -10 |
| 27 | 2025-02-18 | Purdue (13) | 66 | 75 | Michigan State (12) | Final | L | -9 |
| 28 | 2025-02-23 | Purdue (19) | 58 | 73 | Indiana (51) | Final | L | -15 |
| 29 | 2025-02-28 | UCLA (31) | 66 | 76 | Purdue (14) | Final | W | 10 |
| 30 | 2025-03-04 | Rutgers (79) | 71 | 100 | Purdue (12) | Final | W | 29 |
| 31 | 2025-03-07 | Purdue (18) | 80 | 88 | Illinois (22) | Final | L | -8 |
| 32 | 2025-03-13 | USC (67) | 71 | 76 | Purdue (18) | Final | W | 5 |
| 33 | 2025-03-14 | Purdue (18) | 68 | 86 | Michigan (23) | Final | L | -18 |
| 34 | 2025-03-20 | High Point (72) | 63 | 75 | Purdue (20) | Final | W | 12 |
| 35 | 2025-03-22 | McNeese (65) | 62 | 76 | Purdue (20) | Final | W | 14 |
| 36 | 2025-03-28 | Purdue (20) | 60 | 62 | Houston (4) | Final | L | -2 |