Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2024-11-06 | UTRGV (358) | 86 | 99 | Creighton (136) | Final | W | 13 |
| 2 | 2024-11-10 | Fairleigh Dickinson (322) | 70 | 96 | Creighton (63) | Final | W | 26 |
| 3 | 2024-11-13 | Houston Christian (320) | 43 | 78 | Creighton (55) | Final | W | 35 |
| 4 | 2024-11-16 | UMKC (231) | 56 | 79 | Creighton (22) | Final | W | 23 |
| 5 | 2024-11-22 | Nebraska (49) | 74 | 63 | Creighton (70) | Final | L | -11 |
| 6 | 2024-11-26 | Creighton (98) | 53 | 71 | San Diego State (54) | Final | L | -18 |
| 7 | 2024-11-27 | Creighton (106) | 73 | 77 | Texas A&M (60) | Final | L | -4 |
| 8 | 2024-11-30 | Creighton (88) | 80 | 76 | Notre Dame (133) | Final | W | 4 |
| 9 | 2024-12-04 | Kansas (10) | 63 | 76 | Creighton (67) | Final | W | 13 |
| 10 | 2024-12-07 | UNLV (122) | 65 | 83 | Creighton (58) | Final | W | 18 |
| 11 | 2024-12-14 | Creighton (64) | 75 | 83 | Alabama (10) | Final | L | -8 |
| 12 | 2024-12-18 | Creighton (74) | 57 | 81 | Georgetown (64) | Final | L | -24 |
| 13 | 2024-12-21 | Villanova (93) | 79 | 86 | Creighton (68) | Final | W | 7 |
| 14 | 2024-12-31 | St. John's (35) | 56 | 57 | Creighton (59) | Final | W | 1 |
| 15 | 2025-01-03 | Creighton (63) | 71 | 79 | Marquette (5) | Final | L | -8 |
| 16 | 2025-01-11 | Creighton (47) | 80 | 76 | Butler (103) | Final | W | 4 |
| 17 | 2025-01-14 | Providence (93) | 64 | 84 | Creighton (43) | Final | W | 20 |
| 18 | 2025-01-18 | Creighton (39) | 68 | 63 | Connecticut (40) | Final | W | 5 |
| 19 | 2025-01-21 | Creighton (36) | 73 | 49 | DePaul (122) | Final | W | 24 |
| 20 | 2025-01-25 | Seton Hall (209) | 54 | 79 | Creighton (36) | Final | W | 25 |
| 21 | 2025-01-29 | Xavier (61) | 77 | 86 | Creighton (35) | Final | W | 9 |
| 22 | 2025-02-01 | Creighton (37) | 62 | 60 | Villanova (80) | Final | W | 2 |
| 23 | 2025-02-05 | Creighton (32) | 80 | 69 | Providence (97) | Final | W | 11 |
| 24 | 2025-02-08 | Marquette (24) | 67 | 77 | Creighton (29) | Final | W | 10 |
| 25 | 2025-02-11 | Connecticut (40) | 70 | 66 | Creighton (32) | Final | L | -4 |
| 26 | 2025-02-16 | Creighton (34) | 73 | 79 | St. John's (14) | Final | L | -6 |
| 27 | 2025-02-23 | Georgetown (85) | 69 | 80 | Creighton (34) | Final | W | 11 |
| 28 | 2025-02-26 | DePaul (154) | 65 | 75 | Creighton (33) | Final | W | 10 |
| 29 | 2025-03-01 | Creighton (78) | 61 | 83 | Xavier (92) | Final | L | -22 |
| 30 | 2025-03-04 | Creighton (36) | 79 | 61 | Seton Hall (218) | Final | W | 18 |
| 31 | 2025-03-08 | Butler (100) | 74 | 87 | Creighton (36) | Final | W | 13 |
| 32 | 2025-03-13 | DePaul (129) | 81 | 85 | Creighton (38) | Final (2OT) | W | 4 |
| 33 | 2025-03-14 | Connecticut (36) | 62 | 71 | Creighton (38) | Final | W | 9 |
| 34 | 2025-03-15 | Creighton | 66 | 82 | St. John's | Final | L | -16 |
| 35 | 2025-03-20 | Creighton (36) | 89 | 75 | Louisville (10) | Final | W | 14 |
| 36 | 2025-03-22 | Creighton (36) | 70 | 82 | Auburn (1) | Final | L | -12 |