Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Rice | 17 | Arkansas | 38 | Final | L | -21 |
| 2 | 2021-09-11 | Houston | 44 | Rice | 7 | Final | L | -37 |
| 3 | 2021-09-18 | Rice | 0 | Texas | 58 | Final | L | -58 |
| 4 | 2021-09-25 | Texas Southern | 34 | Rice | 48 | Final | W | 14 |
| 5 | 2021-10-02 | Southern Miss | 19 | Rice | 24 | Final | W | 5 |
| 6 | 2021-10-16 | Rice | 0 | UTSA | 45 | Final | L | -45 |
| 7 | 2021-10-23 | Rice | 30 | UAB | 24 | Final | W | 6 |
| 8 | 2021-10-30 | North Texas | 30 | Rice | 24 | Final(OT) | L | -6 |
| 9 | 2021-11-06 | Rice | 24 | Charlotte | 31 | Final(OT) | L | -7 |
| 10 | 2021-11-13 | Western Kentucky | 42 | Rice | 21 | Final | L | -21 |
| 11 | 2021-11-20 | Rice | 28 | UTEP | 38 | Final | L | -10 |
| 12 | 2021-11-27 | Louisiana Tech (129) | 31 | Rice (121) | 35 | Final | W | 4 |