Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-04 | Texas Southern | 25 | Prairie View A&M | 29 | Final | L | -4 |
| 2 | 2016-09-10 | Texas Southern | 20 | Houston Baptist | 24 | Final | L | -4 |
| 3 | 2016-09-17 | Mississippi Valley State | 0 | Texas Southern | 31 | Final | W | 31 |
| 4 | 2016-09-24 | Texas Southern | 31 | Alabama State | 27 | Final | W | 4 |
| 5 | 2016-10-01 | Alabama A&M | 31 | Texas Southern | 34 | Final | W | 3 |
| 6 | 2016-10-15 | Texas Southern | 20 | Alcorn State | 23 | Final | L | -3 |
| 7 | 2016-10-22 | Jackson State | 21 | Texas Southern | 13 | Final | L | -8 |
| 8 | 2016-10-29 | Texas Southern | 17 | Sam Houston State | 66 | Final | L | -49 |
| 9 | 2016-11-05 | Texas Southern (228) | 10 | Southern (156) | 26 | Final | L | -16 |
| 10 | 2016-11-12 | Arkansas-Pine Bluff | 10 | Texas Southern | 27 | Final | W | 17 |
| 11 | 2016-11-19 | Grambling | 47 | Texas Southern | 28 | Final | L | -19 |