Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-04 | Texas Southern | 25 | Prairie View A&M | 29 | Final | W | 4 |
| 2 | 2016-09-10 | Prairie View A&M | 0 | Texas A&M | 67 | Final | L | -67 |
| 3 | 2016-09-17 | Prairie View A&M | 41 | Alabama A&M | 20 | Final | W | 21 |
| 4 | 2016-09-24 | Prairie View A&M | 56 | Mississippi Valley State | 21 | Final | W | 35 |
| 5 | 2016-10-01 | Prairie View A&M | 16 | Grambling | 36 | Final | L | -20 |
| 6 | 2016-10-08 | Alabama State | 17 | Prairie View A&M | 24 | Final/OT | W | 7 |
| 7 | 2016-10-22 | Prairie View A&M | 44 | Rice | 65 | Final | L | -21 |
| 8 | 2016-10-29 | Prairie View A&M | 28 | Jackson State | 14 | Final | W | 14 |
| 9 | 2016-11-05 | Alcorn State | 27 | Prairie View A&M | 31 | Final | W | 4 |
| 10 | 2016-11-12 | Southern | 44 | Prairie View A&M | 34 | Final | L | -10 |
| 11 | 2016-11-19 | Prairie View A&M | 57 | Arkansas-Pine Bluff | 7 | Final | W | 50 |