Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Lynchburg | 12 | Grambling | 72 | Final | W | 60 |
| 2 | 2016-09-10 | Grambling | 21 | Arizona | 31 | Final | L | -10 |
| 3 | 2016-09-17 | Grambling | 35 | Jackson State | 14 | Final | W | 21 |
| 4 | 2016-09-24 | Alcorn State | 18 | Grambling | 43 | Final | W | 25 |
| 5 | 2016-10-01 | Prairie View A&M | 16 | Grambling | 36 | Final | W | 20 |
| 6 | 2016-10-22 | Grambling | 59 | Mississippi Valley State | 10 | Final | W | 49 |
| 7 | 2016-10-29 | Arkansas-Pine Bluff | 0 | Grambling | 70 | Final | W | 70 |
| 8 | 2016-11-05 | Grambling | 56 | Alabama A&M | 17 | Final | W | 39 |
| 9 | 2016-11-12 | Alabama State | 0 | Grambling | 21 | Final | W | 21 |
| 10 | 2016-11-19 | Grambling | 47 | Texas Southern | 28 | Final | W | 19 |
| 11 | 2016-11-26 | Grambling | 52 | Southern | 30 | Final | W | 22 |
| 12 | 2016-12-03 | Grambling | 27 | Alcorn State | 20 | Final | W | 7 |
| 13 | 2016-12-17 | North Carolina Central | 9 | Grambling | 10 | Final | W | 1 |