Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Louisiana | 18 | Texas | 38 | Final | W | 20 |
| 2 | 2021-09-11 | Texas | 21 | Arkansas | 40 | Final | L | -19 |
| 3 | 2021-09-18 | Rice | 0 | Texas | 58 | Final | W | 58 |
| 4 | 2021-09-25 | Texas Tech | 35 | Texas | 70 | Final | W | 35 |
| 5 | 2021-10-02 | Texas | 32 | TCU | 27 | Final | W | 5 |
| 6 | 2021-10-09 | Oklahoma | 55 | Texas | 48 | Final | L | -7 |
| 7 | 2021-10-16 | Oklahoma State | 32 | Texas | 24 | Final | L | -8 |
| 8 | 2021-10-30 | Texas | 24 | Baylor | 31 | Final | L | -7 |
| 9 | 2021-11-06 | Texas | 7 | Iowa State | 30 | Final | L | -23 |
| 10 | 2021-11-13 | Kansas | 57 | Texas | 56 | Final(OT) | L | -1 |
| 11 | 2021-11-20 | Texas | 23 | West Virginia | 31 | Final | L | -8 |
| 12 | 2021-11-26 | Kansas State (42) | 17 | Texas (49) | 22 | Final | W | 5 |