Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Colorado State (103) | 7 | Michigan (3) | 51 | Final | W | 44 |
| 2 | 2022-09-10 | Hawaii (94) | 10 | Michigan (3) | 56 | Final | W | 46 |
| 3 | 2022-09-17 | Connecticut (130) | 0 | Michigan (16) | 59 | Final | W | 59 |
| 4 | 2022-09-24 | Maryland (39) | 27 | Michigan (13) | 34 | Final | W | 7 |
| 5 | 2022-10-01 | Michigan (7) | 27 | Iowa (56) | 14 | Final | W | 13 |
| 6 | 2022-10-08 | Michigan (8) | 31 | Indiana (69) | 10 | Final | W | 21 |
| 7 | 2022-10-15 | Penn State (13) | 17 | Michigan (3) | 41 | Final | W | 24 |
| 8 | 2022-10-29 | Michigan State (67) | 7 | Michigan (6) | 29 | Final | W | 22 |
| 9 | 2022-11-05 | Michigan (3) | 52 | Rutgers (85) | 17 | Final | W | 35 |
| 10 | 2022-11-12 | Nebraska (110) | 3 | Michigan (4) | 34 | Final | W | 31 |
| 11 | 2022-11-19 | Illinois (35) | 17 | Michigan (3) | 19 | Final | W | 2 |
| 12 | 2022-11-26 | Michigan (2) | 45 | Ohio State (4) | 23 | Final | W | 22 |
| 13 | 2022-12-03 | Purdue (43) | 22 | Michigan (2) | 43 | Final | W | 21 |
| 14 | 2022-12-31 | TCU (4) | 51 | Michigan (2) | 45 | Final | L | -6 |