Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Louisville (55) | 7 | Syracuse (78) | 31 | Final | W | 24 |
| 2 | 2022-09-10 | Syracuse (78) | 48 | Connecticut (195) | 14 | Final | W | 34 |
| 3 | 2022-09-17 | Purdue (79) | 29 | Syracuse (10) | 32 | Final | W | 3 |
| 4 | 2022-09-23 | Virginia (72) | 20 | Syracuse (9) | 22 | Final | W | 2 |
| 5 | 2022-10-01 | Wagner (241) | 0 | Syracuse (11) | 59 | Final | W | 59 |
| 6 | 2022-10-15 | North Carolina State (18) | 9 | Syracuse (8) | 24 | Final | W | 15 |
| 7 | 2022-10-22 | Syracuse (8) | 21 | Clemson (1) | 27 | Final | L | -6 |
| 8 | 2022-10-29 | Notre Dame (27) | 41 | Syracuse (15) | 24 | Final | L | -17 |
| 9 | 2022-11-05 | Syracuse (22) | 9 | Pittsburgh (55) | 19 | Final | L | -10 |
| 10 | 2022-11-12 | Florida State (15) | 38 | Syracuse (28) | 3 | Final | L | -35 |
| 11 | 2022-11-19 | Syracuse (37) | 35 | Wake Forest (25) | 45 | Final | L | -10 |
| 12 | 2022-11-26 | Syracuse (40) | 32 | Boston College (117) | 23 | Final | W | 9 |
| 13 | 2022-12-29 | Syracuse (39) | 20 | Minnesota (34) | 28 | Final | L | -8 |