Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-05 | Penn State (62) | 10 | Temple (83) | 27 | Final | L | -17 |
| 2 | 2015-09-12 | Buffalo (115) | 14 | Penn State (62) | 27 | Final | W | 13 |
| 3 | 2015-09-19 | Rutgers (108) | 3 | Penn State (60) | 28 | Final | W | 25 |
| 4 | 2015-09-26 | San Diego State (108) | 21 | Penn State (41) | 37 | Final | W | 16 |
| 5 | 2015-10-03 | Army (122) | 14 | Penn State (40) | 20 | Final | W | 6 |
| 6 | 2015-10-10 | Indiana (34) | 7 | Penn State (37) | 29 | Final | W | 22 |
| 7 | 2015-10-17 | Penn State (27) | 10 | Ohio State (4) | 38 | Final | L | -28 |
| 8 | 2015-10-24 | Penn State (37) | 31 | Maryland (81) | 30 | Final | W | 1 |
| 9 | 2015-10-31 | Illinois (47) | 0 | Penn State (37) | 39 | Final | W | 39 |
| 10 | 2015-11-07 | Penn State (34) | 21 | Northwestern (24) | 23 | Final | L | -2 |
| 11 | 2015-11-21 | Michigan (10) | 28 | Penn State (40) | 16 | Final | L | -12 |
| 12 | 2015-11-28 | Penn State (43) | 16 | Michigan State (7) | 55 | Final | L | -39 |
| 13 | 2016-01-02 | Penn State (47) | 17 | Georgia (34) | 24 | Final | L | -7 |