Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-05 | Albany | 14 | Buffalo | 51 | Final | W | 37 |
| 2 | 2015-09-12 | Buffalo (115) | 14 | Penn State (62) | 27 | Final | L | -13 |
| 3 | 2015-09-19 | Buffalo | 33 | Florida Atlantic | 15 | Final | W | 18 |
| 4 | 2015-09-26 | Nevada (96) | 24 | Buffalo (69) | 21 | Final | L | -3 |
| 5 | 2015-10-03 | Bowling Green (64) | 28 | Buffalo (79) | 22 | Final | L | -6 |
| 6 | 2015-10-17 | Buffalo | 14 | Central Michigan | 51 | Final | L | -37 |
| 7 | 2015-10-24 | Ohio (68) | 17 | Buffalo (101) | 41 | Final | W | 24 |
| 8 | 2015-10-29 | Buffalo (89) | 29 | Miami (OH) (122) | 24 | Final | W | 5 |
| 9 | 2015-11-05 | Buffalo (82) | 18 | Kent State (108) | 17 | Final | W | 1 |
| 10 | 2015-11-11 | Northern Illinois | 41 | Buffalo | 30 | Final | L | -11 |
| 11 | 2015-11-21 | Buffalo (84) | 21 | Akron (90) | 42 | Final | L | -21 |
| 12 | 2015-11-27 | Massachusetts | 31 | Buffalo | 26 | Final | L | -5 |