Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-07 | Ohio State (6) | 42 | Virginia Tech (55) | 24 | Final | W | 18 |
| 2 | 2015-09-12 | Hawaii (106) | 0 | Ohio State (6) | 38 | Final | W | 38 |
| 3 | 2015-09-19 | Northern Illinois | 13 | Ohio State | 20 | Final | W | 7 |
| 4 | 2015-09-26 | Western Michigan | 12 | Ohio State | 38 | Final | W | 26 |
| 5 | 2015-10-03 | Ohio State (9) | 34 | Indiana (25) | 27 | Final | W | 7 |
| 6 | 2015-10-10 | Maryland (86) | 28 | Ohio State (5) | 49 | Final | W | 21 |
| 7 | 2015-10-17 | Penn State (27) | 10 | Ohio State (4) | 38 | Final | W | 28 |
| 8 | 2015-10-24 | Ohio State (2) | 49 | Rutgers (69) | 7 | Final | W | 42 |
| 9 | 2015-11-07 | Minnesota (59) | 14 | Ohio State (3) | 28 | Final | W | 14 |
| 10 | 2015-11-14 | Ohio State (3) | 28 | Illinois (54) | 3 | Final | W | 25 |
| 11 | 2015-11-21 | Michigan State (16) | 17 | Ohio State (3) | 14 | Final | L | -3 |
| 12 | 2015-11-28 | Ohio State (5) | 42 | Michigan (9) | 13 | Final | W | 29 |
| 13 | 2016-01-01 | Notre Dame (11) | 28 | Ohio State (4) | 44 | Final | W | 16 |