Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-08-31 | Ohio State (3) | 49 | Indiana (65) | 21 | Final | W | 28 |
| 2 | 2017-09-09 | Oklahoma (6) | 31 | Ohio State (3) | 16 | Final | L | -15 |
| 3 | 2017-09-16 | Army (69) | 7 | Ohio State (3) | 38 | Final | W | 31 |
| 4 | 2017-09-23 | UNLV (110) | 21 | Ohio State (3) | 54 | Final | W | 33 |
| 5 | 2017-09-30 | Ohio State (19) | 56 | Rutgers (121) | 0 | Final | W | 56 |
| 6 | 2017-10-07 | Maryland (32) | 14 | Ohio State (16) | 62 | Final | W | 48 |
| 7 | 2017-10-14 | Ohio State (13) | 56 | Nebraska (56) | 14 | Final | W | 42 |
| 8 | 2017-10-28 | Penn State (2) | 38 | Ohio State (10) | 39 | Final | W | 1 |
| 9 | 2017-11-04 | Ohio State (5) | 24 | Iowa (26) | 55 | Final | L | -31 |
| 10 | 2017-11-11 | Michigan State (14) | 3 | Ohio State (10) | 48 | Final | W | 45 |
| 11 | 2017-11-18 | Illinois (118) | 14 | Ohio State (9) | 52 | Final | W | 38 |
| 12 | 2017-11-25 | Ohio State (8) | 31 | Michigan (20) | 20 | Final | W | 11 |
| 13 | 2017-12-02 | Ohio State (7) | 27 | Wisconsin (1) | 21 | Final | W | 6 |
| 14 | 2017-12-29 | USC (13) | 7 | Ohio State (5) | 24 | Final | W | 17 |