Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Notre Dame (8) | 10 | Ohio State (4) | 21 | Final | L | -11 |
| 2 | 2022-09-10 | Marshall (70) | 26 | Notre Dame (8) | 21 | Final | L | -5 |
| 3 | 2022-09-17 | California (68) | 17 | Notre Dame (73) | 24 | Final | W | 7 |
| 4 | 2022-09-24 | Notre Dame (52) | 45 | North Carolina (55) | 32 | Final | W | 13 |
| 5 | 2022-10-08 | BYU (38) | 20 | Notre Dame (30) | 28 | Final | W | 8 |
| 6 | 2022-10-15 | Stanford (78) | 16 | Notre Dame (47) | 14 | Final | L | -2 |
| 7 | 2022-10-22 | UNLV (97) | 21 | Notre Dame (40) | 44 | Final | W | 23 |
| 8 | 2022-10-29 | Notre Dame (27) | 41 | Syracuse (15) | 24 | Final | W | 17 |
| 9 | 2022-11-05 | Clemson (10) | 14 | Notre Dame (18) | 35 | Final | W | 21 |
| 10 | 2022-11-12 | Notre Dame (20) | 35 | Navy (108) | 32 | Final | W | 3 |
| 11 | 2022-11-19 | Boston College (109) | 0 | Notre Dame (16) | 44 | Final | W | 44 |
| 12 | 2022-11-26 | Notre Dame (20) | 27 | USC (7) | 38 | Final | L | -11 |
| 13 | 2022-12-30 | Notre Dame (22) | 45 | South Carolina (25) | 38 | Final | W | 7 |