Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-05 | Clemson (13) | 41 | Georgia Tech (102) | 10 | Final | W | 31 |
| 2 | 2022-09-10 | Furman (172) | 12 | Clemson (13) | 35 | Final | W | 23 |
| 3 | 2022-09-17 | Louisiana Tech (114) | 20 | Clemson (27) | 48 | Final | W | 28 |
| 4 | 2022-09-24 | Clemson (15) | 51 | Wake Forest (25) | 45 | Final(OT) | W | 6 |
| 5 | 2022-10-01 | North Carolina State (21) | 20 | Clemson (3) | 30 | Final | W | 10 |
| 6 | 2022-10-08 | Clemson (4) | 31 | Boston College (110) | 3 | Final | W | 28 |
| 7 | 2022-10-15 | Clemson (4) | 34 | Florida State (31) | 28 | Final | W | 6 |
| 8 | 2022-10-22 | Syracuse (8) | 21 | Clemson (1) | 27 | Final | W | 6 |
| 9 | 2022-11-05 | Clemson (10) | 14 | Notre Dame (18) | 35 | Final | L | -21 |
| 10 | 2022-11-12 | Louisville (27) | 16 | Clemson (8) | 31 | Final | W | 15 |
| 11 | 2022-11-19 | Miami (79) | 10 | Clemson (8) | 40 | Final | W | 30 |
| 12 | 2022-11-26 | South Carolina (24) | 31 | Clemson (12) | 30 | Final | L | -1 |
| 13 | 2022-12-03 | Clemson (12) | 39 | North Carolina (41) | 10 | Final | W | 29 |
| 14 | 2022-12-30 | Tennessee (5) | 31 | Clemson (12) | 14 | Final | L | -17 |