Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Louisiana Tech (127) | 24 | Missouri (72) | 52 | Final | W | 28 |
| 2 | 2022-09-10 | Missouri (72) | 12 | Kansas State (37) | 40 | Final | L | -28 |
| 3 | 2022-09-17 | Abilene Christian (152) | 17 | Missouri (78) | 34 | Final | W | 17 |
| 4 | 2022-09-24 | Missouri (84) | 14 | Auburn (41) | 17 | Final(OT) | L | -3 |
| 5 | 2022-10-01 | Georgia (4) | 26 | Missouri (81) | 22 | Final | L | -4 |
| 6 | 2022-10-08 | Missouri (81) | 17 | Florida (42) | 24 | Final | L | -7 |
| 7 | 2022-10-22 | Vanderbilt (93) | 14 | Missouri (77) | 17 | Final | W | 3 |
| 8 | 2022-10-29 | Missouri (59) | 23 | South Carolina (51) | 10 | Final | W | 13 |
| 9 | 2022-11-05 | Kentucky (36) | 21 | Missouri (65) | 17 | Final | L | -4 |
| 10 | 2022-11-12 | Missouri (70) | 24 | Tennessee (3) | 66 | Final | L | -42 |
| 11 | 2022-11-19 | New Mexico State (138) | 14 | Missouri (68) | 45 | Final | W | 31 |
| 12 | 2022-11-25 | Arkansas (47) | 27 | Missouri (54) | 29 | Final | W | 2 |
| 13 | 2022-12-23 | Wake Forest (38) | 27 | Missouri (51) | 17 | Final | L | -10 |