Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2024-11-04 | American (249) | 52 | 65 | La Salle (237) | Final | W | 13 |
| 2 | 2024-11-09 | Lafayette (323) | 60 | 81 | La Salle (237) | Final | W | 21 |
| 3 | 2024-11-12 | Cornell (160) | 77 | 93 | La Salle (12) | Final | W | 16 |
| 4 | 2024-11-16 | La Salle (24) | 71 | 68 | Drexel (190) | Final | W | 3 |
| 5 | 2024-11-21 | La Salle (96) | 67 | 72 | UC-San Diego (148) | Final | L | -5 |
| 6 | 2024-11-22 | La Salle (122) | 83 | 96 | Illinois-Chicago (139) | Final | L | -13 |
| 7 | 2024-11-23 | La Salle (237) | 92 | 77 | Stetson (301) | Final | W | 15 |
| 8 | 2024-11-30 | Temple (134) | 75 | 83 | La Salle (91) | Final | W | 8 |
| 9 | 2024-12-03 | La Salle (118) | 68 | 82 | Northeastern (130) | Final | L | -14 |
| 10 | 2024-12-07 | Saint Joseph's (97) | 82 | 68 | La Salle (140) | Final | L | -14 |
| 11 | 2024-12-14 | La Salle (148) | 67 | 93 | North Carolina (50) | Final | L | -26 |
| 12 | 2024-12-18 | Fairleigh Dickinson (328) | 72 | 77 | La Salle (132) | Final | W | 5 |
| 13 | 2024-12-21 | Immaculata | 48 | 108 | La Salle (129) | Final | W | 60 |
| 14 | 2024-12-31 | La Salle (135) | 70 | 84 | Dayton (38) | Final | L | -14 |
| 15 | 2025-01-08 | Loyola-Chicago (120) | 79 | 68 | La Salle (159) | Final | L | -11 |
| 16 | 2025-01-11 | La Salle (139) | 83 | 82 | St. Bonaventure (70) | Final (OT) | W | 1 |
| 17 | 2025-01-15 | Davidson (94) | 76 | 79 | La Salle (141) | Final | W | 3 |
| 18 | 2025-01-19 | La Salle (150) | 60 | 82 | Massachusetts (202) | Final | L | -22 |
| 19 | 2025-01-22 | La Salle (160) | 52 | 64 | Saint Louis (117) | Final | L | -12 |
| 20 | 2025-01-25 | Rhode Island (101) | 64 | 70 | La Salle (147) | Final | W | 6 |
| 21 | 2025-01-29 | Fordham (201) | 88 | 72 | La Salle (159) | Final | L | -16 |
| 22 | 2025-02-01 | George Washington (127) | 67 | 73 | La Salle (148) | Final | W | 6 |
| 23 | 2025-02-04 | La Salle (157) | 66 | 96 | Virginia Commonwealth (52) | Final | L | -30 |
| 24 | 2025-02-09 | Massachusetts (182) | 78 | 55 | La Salle (237) | Final | L | -23 |
| 25 | 2025-02-12 | La Salle (175) | 63 | 75 | Saint Joseph's (88) | Final | L | -12 |
| 26 | 2025-02-15 | La Salle (180) | 71 | 86 | Rhode Island (101) | Final | L | -15 |
| 27 | 2025-02-19 | Richmond (241) | 63 | 58 | La Salle (198) | Final | L | -5 |
| 28 | 2025-02-26 | Duquesne (175) | 67 | 62 | La Salle (200) | Final | L | -5 |
| 29 | 2025-03-01 | La Salle (237) | 60 | 71 | George Washington (104) | Final | L | -11 |
| 30 | 2025-03-05 | La Salle (206) | 62 | 69 | George Mason (62) | Final | L | -7 |
| 31 | 2025-03-08 | Saint Joseph's (83) | 74 | 81 | La Salle (188) | Final | W | 7 |
| 32 | 2025-03-12 | La Salle (180) | 78 | 71 | Massachusetts (212) | Final | W | 7 |
| 33 | 2025-03-13 | La Salle (180) | 70 | 75 | Saint Joseph's (80) | Final | L | -5 |