Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Virginia Military (175) | 10 | Wake Forest (16) | 44 | Final | W | 34 |
| 2 | 2022-09-10 | Wake Forest (16) | 45 | Vanderbilt (150) | 25 | Final | W | 20 |
| 3 | 2022-09-17 | Liberty (35) | 36 | Wake Forest (7) | 37 | Final | W | 1 |
| 4 | 2022-09-24 | Clemson (15) | 51 | Wake Forest (25) | 45 | Final(OT) | L | -6 |
| 5 | 2022-10-01 | Wake Forest (15) | 31 | Florida State (20) | 21 | Final | W | 10 |
| 6 | 2022-10-08 | Army (121) | 10 | Wake Forest (15) | 45 | Final | W | 35 |
| 7 | 2022-10-22 | Boston College (106) | 15 | Wake Forest (11) | 43 | Final | W | 28 |
| 8 | 2022-10-29 | Wake Forest (21) | 21 | Louisville (33) | 48 | Final | L | -27 |
| 9 | 2022-11-05 | Wake Forest (30) | 21 | North Carolina State (16) | 30 | Final | L | -9 |
| 10 | 2022-11-12 | North Carolina (17) | 36 | Wake Forest (34) | 34 | Final | L | -2 |
| 11 | 2022-11-19 | Syracuse (37) | 35 | Wake Forest (25) | 45 | Final | W | 10 |
| 12 | 2022-11-26 | Wake Forest (38) | 31 | Duke (52) | 34 | Final | L | -3 |
| 13 | 2022-12-23 | Wake Forest (38) | 27 | Missouri (51) | 17 | Final | W | 10 |