Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-02 | Temple (143) | 0 | Duke (136) | 30 | Final | W | 30 |
| 2 | 2022-09-10 | Duke (136) | 31 | Northwestern (112) | 23 | Final | W | 8 |
| 3 | 2022-09-17 | North Carolina A&T (239) | 20 | Duke (32) | 49 | Final | W | 29 |
| 4 | 2022-09-24 | Duke (45) | 27 | Kansas (7) | 35 | Final | L | -8 |
| 5 | 2022-10-01 | Virginia (86) | 17 | Duke (31) | 38 | Final | W | 21 |
| 6 | 2022-10-08 | Duke (54) | 20 | Georgia Tech (61) | 23 | Final(OT) | L | -3 |
| 7 | 2022-10-15 | North Carolina (30) | 38 | Duke (65) | 35 | Final | L | -3 |
| 8 | 2022-10-22 | Duke (55) | 45 | Miami (89) | 21 | Final | W | 24 |
| 9 | 2022-11-04 | Duke (54) | 38 | Boston College (124) | 31 | Final | W | 7 |
| 10 | 2022-11-12 | Virginia Tech (128) | 7 | Duke (53) | 24 | Final | W | 17 |
| 11 | 2022-11-19 | Duke (58) | 26 | Pittsburgh (47) | 28 | Final | L | -2 |
| 12 | 2022-11-26 | Wake Forest (38) | 31 | Duke (52) | 34 | Final | W | 3 |
| 13 | 2022-12-28 | Central Florida (31) | 13 | Duke (55) | 30 | Final | W | 17 |