Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-08-30 | Southern Illinois | 49 | Murray State | 10 | Final | W | 39 |
| 2 | 2018-09-08 | Southern Illinois | 41 | Ole Miss | 76 | Final | L | -35 |
| 3 | 2018-09-15 | Southeast Missouri State | 48 | Southern Illinois | 44 | Final | L | -4 |
| 4 | 2018-09-29 | South Dakota (193) | 31 | Southern Illinois (197) | 24 | Final | L | -7 |
| 5 | 2018-10-06 | Southern Illinois (202) | 14 | Youngstown State (222) | 17 | Final | L | -3 |
| 6 | 2018-10-13 | Southern Illinois (216) | 3 | Illinois State (133) | 51 | Final | L | -48 |
| 7 | 2018-10-20 | Indiana State (203) | 24 | Southern Illinois (219) | 21 | Final | L | -3 |
| 8 | 2018-10-27 | Southern Illinois (224) | 49 | Missouri State (170) | 35 | Final | W | 14 |
| 9 | 2018-11-03 | Western Illinois (161) | 34 | Southern Illinois (211) | 31 | Final | L | -3 |
| 10 | 2018-11-10 | South Dakota State (122) | 57 | Southern Illinois (217) | 38 | Final | L | -19 |
| 11 | 2018-11-17 | Southern Illinois (215) | 17 | North Dakota State (84) | 65 | Final | L | -48 |