Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Southeast Missouri State | 21 | Arkansas State | 48 | Final | L | -27 |
| 2 | 2018-09-08 | Dayton | 21 | Southeast Missouri State | 40 | Final | W | 19 |
| 3 | 2018-09-15 | Southeast Missouri State | 48 | Southern Illinois | 44 | Final | W | 4 |
| 4 | 2018-09-22 | Southeast Missouri State | 14 | Eastern Kentucky | 23 | Final | L | -9 |
| 5 | 2018-10-06 | Southeast Missouri State (175) | 70 | Tennessee Tech (253) | 38 | Final | W | 32 |
| 6 | 2018-10-13 | Austin Peay (183) | 27 | Southeast Missouri State (173) | 31 | Final | W | 4 |
| 7 | 2018-10-20 | Jacksonville State (138) | 14 | Southeast Missouri State (168) | 37 | Final | W | 23 |
| 8 | 2018-10-27 | Southeast Missouri State (157) | 56 | Tennessee-Martin (223) | 33 | Final | W | 23 |
| 9 | 2018-11-03 | Tennessee State (194) | 21 | Southeast Missouri State (151) | 38 | Final | W | 17 |
| 10 | 2018-11-10 | Southeast Missouri State (143) | 38 | Murray State (206) | 40 | Final | L | -2 |
| 11 | 2018-11-17 | Eastern Illinois (221) | 32 | Southeast Missouri State (155) | 38 | Final | W | 6 |
| 12 | 2018-11-24 | Stony Brook (142) | 14 | Southeast Missouri State (154) | 28 | Final | W | 14 |
| 13 | 2018-12-01 | Southeast Missouri State (142) | 23 | Weber State (127) | 48 | Final | L | -25 |