Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-05 | Southern Illinois | 47 | Indiana | 48 | Final | L | -1 |
| 2 | 2015-09-12 | Southern Illinois | 24 | Southeast Missouri State | 27 | Final | L | -3 |
| 3 | 2015-09-26 | Liberty | 13 | Southern Illinois | 34 | Final | W | 21 |
| 4 | 2015-10-03 | Southern Illinois | 36 | Western Illinois | 37 | Final | L | -1 |
| 5 | 2015-10-10 | Missouri State | 26 | Southern Illinois | 73 | Final | W | 47 |
| 6 | 2015-10-17 | Southern Illinois | 36 | Indiana State | 39 | Final | L | -3 |
| 7 | 2015-10-24 | Youngstown State | 31 | Southern Illinois | 38 | Final/OT | W | 7 |
| 8 | 2015-10-31 | North Dakota State | 35 | Southern Illinois | 29 | Final | L | -6 |
| 9 | 2015-11-07 | Southern Illinois | 31 | South Dakota | 34 | Final | L | -3 |
| 10 | 2015-11-14 | Illinois State | 42 | Southern Illinois | 21 | Final | L | -21 |
| 11 | 2015-11-21 | Southern Illinois | 28 | Northern Iowa | 49 | Final | L | -21 |