Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-05 | Southeast Missouri State | 3 | Missouri | 34 | Final | L | -31 |
| 2 | 2015-09-12 | Southern Illinois | 24 | Southeast Missouri State | 27 | Final | W | 3 |
| 3 | 2015-09-19 | Southeast Missouri State | 28 | Indiana State | 29 | Final | L | -1 |
| 4 | 2015-09-26 | Shorter | 26 | Southeast Missouri State | 21 | Final | L | -5 |
| 5 | 2015-10-03 | Murray State | 10 | Southeast Missouri State | 27 | Final | W | 17 |
| 6 | 2015-10-10 | Southeast Missouri State | 28 | Eastern Illinois | 33 | Final | L | -5 |
| 7 | 2015-10-17 | Eastern Kentucky | 27 | Southeast Missouri State | 10 | Final | L | -17 |
| 8 | 2015-10-31 | Tennessee Tech | 17 | Southeast Missouri State | 38 | Final | W | 21 |
| 9 | 2015-11-07 | Southeast Missouri State | 44 | Austin Peay | 15 | Final | W | 29 |
| 10 | 2015-11-14 | Southeast Missouri State | 28 | Jacksonville State | 56 | Final | L | -28 |
| 11 | 2015-11-21 | Tennessee-Martin | 28 | Southeast Missouri State | 25 | Final | L | -3 |