Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-03 | Eastern Illinois | 5 | Western Illinois | 33 | Final | L | -28 |
| 2 | 2015-09-12 | Eastern Illinois | 0 | Northwestern | 41 | Final | L | -41 |
| 3 | 2015-09-19 | Illinois State | 34 | Eastern Illinois | 31 | Final/OT | L | -3 |
| 4 | 2015-10-03 | Eastern Illinois | 40 | Austin Peay | 16 | Final | W | 24 |
| 5 | 2015-10-10 | Southeast Missouri State | 28 | Eastern Illinois | 33 | Final | W | 5 |
| 6 | 2015-10-17 | Eastern Illinois | 25 | Tennessee State | 22 | Final/OT | W | 3 |
| 7 | 2015-10-24 | Tennessee Tech | 20 | Eastern Illinois | 51 | Final | W | 31 |
| 8 | 2015-10-31 | Eastern Illinois | 34 | Murray State | 20 | Final | W | 14 |
| 9 | 2015-11-07 | Jacksonville State | 24 | Eastern Illinois | 3 | Final | L | -21 |
| 10 | 2015-11-14 | Eastern Illinois | 23 | Tennessee-Martin | 21 | Final | W | 2 |
| 11 | 2015-11-21 | Eastern Kentucky | 7 | Eastern Illinois | 21 | Final | W | 14 |
| 12 | 2015-11-28 | Eastern Illinois | 17 | Northern Iowa | 53 | Final | L | -36 |