Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-03 | Kentucky Wesleyan | 12 | Murray State | 52 | Final | W | 40 |
| 2 | 2015-09-12 | Murray State | 26 | Northern Illinois | 57 | Final | L | -31 |
| 3 | 2015-09-19 | Murray State | 20 | Western Michigan | 52 | Final | L | -32 |
| 4 | 2015-09-26 | Tennessee Tech | 31 | Murray State | 29 | Final | L | -2 |
| 5 | 2015-10-03 | Murray State | 10 | Southeast Missouri State | 27 | Final | L | -17 |
| 6 | 2015-10-10 | Austin Peay | 18 | Murray State | 34 | Final | W | 16 |
| 7 | 2015-10-24 | Murray State | 45 | Tennessee-Martin | 52 | Final | L | -7 |
| 8 | 2015-10-31 | Eastern Illinois | 34 | Murray State | 20 | Final | L | -14 |
| 9 | 2015-11-07 | Murray State | 46 | Tennessee State | 43 | Final/OT | W | 3 |
| 10 | 2015-11-14 | Eastern Kentucky | 41 | Murray State | 34 | Final/2OT | L | -7 |
| 11 | 2015-11-21 | Murray State | 20 | Jacksonville State | 42 | Final | L | -22 |