Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | North Carolina A&T (188) | 13 | North Carolina Central (210) | 28 | Final | L | -15 |
| 2 | 2022-09-10 | North Carolina A&T (188) | 3 | North Dakota State (54) | 43 | Final | L | -40 |
| 3 | 2022-09-17 | North Carolina A&T (239) | 20 | Duke (32) | 49 | Final | L | -29 |
| 4 | 2022-09-24 | South Carolina State (207) | 27 | North Carolina A&T (196) | 47 | Final | W | 20 |
| 5 | 2022-10-01 | Bryant (228) | 13 | North Carolina A&T (189) | 24 | Final | W | 11 |
| 6 | 2022-10-15 | Edward Waters | 7 | North Carolina A&T (193) | 45 | Final | W | 38 |
| 7 | 2022-10-22 | North Carolina A&T (186) | 38 | Robert Morris (256) | 14 | Final | W | 24 |
| 8 | 2022-10-29 | Campbell (176) | 38 | North Carolina A&T (179) | 45 | Final | W | 7 |
| 9 | 2022-11-05 | Norfolk State (249) | 24 | North Carolina A&T (173) | 49 | Final | W | 25 |
| 10 | 2022-11-12 | Charleston Southern (235) | 10 | North Carolina A&T (174) | 20 | Final | W | 10 |
| 11 | 2022-11-19 | North Carolina A&T (182) | 17 | Gardner-Webb (163) | 38 | Final | L | -21 |