Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-02 | Northwestern State | 7 | Baylor | 55 | Final | L | -48 |
| 2 | 2016-09-08 | Incarnate Word | 21 | Northwestern State | 18 | Final | L | -3 |
| 3 | 2016-09-17 | Northwestern State | 10 | Central Arkansas | 24 | Final | L | -14 |
| 4 | 2016-09-24 | Northwestern State | 24 | Southeastern Louisiana | 34 | Final | L | -10 |
| 5 | 2016-10-08 | Kentucky Wesleyan | 7 | Northwestern State | 49 | Final | W | 42 |
| 6 | 2016-10-15 | Northwestern State | 31 | Lamar | 32 | Final | L | -1 |
| 7 | 2016-10-22 | McNeese State | 48 | Northwestern State | 27 | Final | L | -21 |
| 8 | 2016-10-29 | Nicholls State | 31 | Northwestern State | 14 | Final | L | -17 |
| 9 | 2016-11-05 | Northwestern State | 22 | Abilene Christian | 25 | Final | L | -3 |
| 10 | 2016-11-12 | Sam Houston State | 48 | Northwestern State | 16 | Final | L | -32 |
| 11 | 2016-11-19 | Northwestern State | 31 | Stephen F. Austin | 45 | Final | L | -14 |